ID A6JYI0_RAT Unreviewed; 372 AA. AC A6JYI0; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 27-NOV-2024, entry version 6. DE SubName: Full=Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a {ECO:0000313|EMBL:EDL83291.1}; GN Name=Kcnj1 {ECO:0000313|EMBL:EDL83291.1, ECO:0000313|RGD:2957}; GN ORFNames=rCG_22731 {ECO:0000313|EMBL:EDL83291.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:EDL83291.1}; RN [1] {ECO:0000313|EMBL:EDL83291.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL83291.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [2] {ECO:0000313|EMBL:EDL83291.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL83291.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}. CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC CC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH474007; EDL83291.1; -; Genomic_DNA. DR RefSeq; NP_001296226.1; NM_001309297.1. DR RefSeq; XP_008764269.1; XM_008766047.2. DR RefSeq; XP_017450947.1; XM_017595458.1. DR GeneID; 24521; -. DR KEGG; rno:24521; -. DR CTD; 3758; -. DR RGD; 2957; Kcnj1. DR Proteomes; UP000234681; Chromosome 8. DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW. DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro. DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:InterPro. DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:InterPro. DR FunFam; 1.10.287.70:FF:000036; ATP-sensitive inward rectifier potassium channel 1; 1. DR FunFam; 2.60.40.1400:FF:000002; ATP-sensitive inward rectifier potassium channel 1; 1. DR Gene3D; 1.10.287.70; -; 1. DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR041647; IRK_C. DR InterPro; IPR016449; K_chnl_inward-rec_Kir. DR InterPro; IPR003268; K_chnl_inward-rec_Kir1.1. DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto. DR InterPro; IPR040445; Kir_TM. DR PANTHER; PTHR11767:SF6; ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1; 1. DR PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1. DR Pfam; PF01007; IRK; 1. DR Pfam; PF17655; IRK_C; 1. DR PIRSF; PIRSF005465; GIRK_kir; 1. DR PRINTS; PR01321; KIR11CHANNEL. DR PRINTS; PR01320; KIRCHANNEL. DR SUPFAM; SSF81296; E set domains; 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1. PE 3: Inferred from homology; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU003822}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538, KW ECO:0000256|RuleBase:RU003822}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003822}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822}; KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882, KW ECO:0000256|RuleBase:RU003822}. FT TRANSMEM 64..86 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 137..161 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 24..166 FT /note="Potassium channel inwardly rectifying transmembrane" FT /evidence="ECO:0000259|Pfam:PF01007" FT DOMAIN 173..345 FT /note="Inward rectifier potassium channel C-terminal" FT /evidence="ECO:0000259|Pfam:PF17655" FT SITE 152 FT /note="Role in the control of polyamine-mediated channel FT gating and in the blocking by intracellular magnesium" FT /evidence="ECO:0000256|PIRSR:PIRSR005465-1" SQ SEQUENCE 372 AA; 42776 MW; F606EC799ECD3F3F CRC64; MFKHLRRWFV THIFGRSRQR ARLVSKEGRC NIEFGNVDAQ SRFIFFVDIW TTVLDLKWRY KMTVFITAFL GSWFLFGLLW YVVAYVHKDL PEFYPPDNRT PCVENINGMT SAFLFSLETQ VTIGYGFRFV TEQCATAIFL LIFQSILGVI INSFMCGAIL AKISRPKKRA KTITFSKNAV ISKRGGKLCL LIRVANLRKS LLIGSHIYGK LLKTTITPEG ETIILDQTNI NFVVDAGNEN LFFISPLTIY HIIDHNSPFF HMAAETLSQQ DFELVVFLDG TVESTSATCQ VRTSYVPEEV LWGYRFVPIV SKTKEGKYRV DFHNFGKTVE VETPHCAMCL YNEKDARARM KRGYDNPNFV LSEVDETDDT QM //