ID A6IQ73_RAT Unreviewed; 300 AA. AC A6IQ73; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 27-MAR-2024, entry version 5. DE RecName: Full=Acyltransferase {ECO:0000256|RuleBase:RU367023}; DE EC=2.3.1.- {ECO:0000256|RuleBase:RU367023}; GN Name=Awat2 {ECO:0000313|RGD:1565111}; GN Synonyms=Dgat2l4_predicted {ECO:0000313|EMBL:EDL95940.1}; GN ORFNames=rCG_36461 {ECO:0000313|EMBL:EDL95940.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:EDL95940.1, ECO:0000313|Proteomes:UP000234681}; RN [1] {ECO:0000313|EMBL:EDL95940.1, ECO:0000313|Proteomes:UP000234681} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BN, Sprague-Dawley {ECO:0000313|Proteomes:UP000234681}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU367023}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU367023}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the diacylglycerol acyltransferase family. CC {ECO:0000256|ARBA:ARBA00005420, ECO:0000256|RuleBase:RU367023}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU367023}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH473966; EDL95940.1; -; Genomic_DNA. DR RGD; 1565111; Awat2. DR Proteomes; UP000234681; Chromosome x. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro. DR GO; GO:0044255; P:cellular lipid metabolic process; IEA:UniProt. DR CDD; cd07987; LPLAT_MGAT-like; 1. DR InterPro; IPR007130; DAGAT. DR PANTHER; PTHR12317:SF19; ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 2-RELATED; 1. DR PANTHER; PTHR12317; DIACYLGLYCEROL O-ACYLTRANSFERASE; 1. DR Pfam; PF03982; DAGAT; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000313|EMBL:EDL95940.1}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU367023}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367023}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367023}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU367023}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU367023}. FT TRANSMEM 6..25 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367023" SQ SEQUENCE 300 AA; 34458 MW; 9D63EB689ED052C9 CRC64; MVNLYLVVFT SFWPVTVLML LWLAFDWKTP ERGGRRFNCV RRWCLWKHYS NYFPLKIVKT KDIPTNHNYI LACHPHGLLS HSWFGHFSTD TTGFSKIFPG ITPYMLTLGA FFWVPFLREY IMSTGACSVS QSSIDFLLTQ KGTGNMLVVV VGGLAECKYS MPGSTTLFLK KRQGFVRTAL RYGVSLIPAY AFGEADLYDQ HIFTPGSFIS HFQKWFQKMV HVYPCAFYGR GFTKNSWGLL PYSQPVTTIV GEPLPLPKIE NPSQEIVAKY HTLYIDALRK LFDQHKTKFG ISETQELVII //