ID A6IB70_RAT Unreviewed; 311 AA. AC A6IB70; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 13-SEP-2023, entry version 2. DE RecName: Full=Vomeronasal type-1 receptor {ECO:0000256|RuleBase:RU364061}; GN Name=V1ra12_predicted {ECO:0000313|EMBL:EDL91338.1}; GN ORFNames=rCG_56539 {ECO:0000313|EMBL:EDL91338.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:EDL91338.1}; RN [1] {ECO:0000313|EMBL:EDL91338.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL91338.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [2] {ECO:0000313|EMBL:EDL91338.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL91338.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of CC social as well as reproductive behavior. CC {ECO:0000256|ARBA:ARBA00002233}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU364061}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU364061}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH473957; EDL91338.1; -; Genomic_DNA. DR Proteomes; UP000234681; Chromosome 4. DR CDD; cd13949; 7tm_V1R_pheromone; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR004072; Vmron_rcpt_1. DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1. DR PANTHER; PTHR24062:SF167; VOMERONASAL TYPE-1 RECEPTOR 42-RELATED; 1. DR Pfam; PF03402; V1R; 1. DR PRINTS; PR01534; VOMERONASL1R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|RuleBase:RU364061}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU364061}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364061}; KW Pheromone response {ECO:0000256|ARBA:ARBA00022507, KW ECO:0000256|RuleBase:RU364061}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU364061}; KW Transducer {ECO:0000256|RuleBase:RU364061}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU364061}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU364061}. FT TRANSMEM 22..41 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT TRANSMEM 53..76 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT TRANSMEM 136..157 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT TRANSMEM 190..213 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT TRANSMEM 240..258 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT TRANSMEM 270..290 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU364061" FT DOMAIN 29..290 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 311 AA; 35589 MW; 27A5D881AE9226D0 CRC64; MMNKNSRVHT DSNIRNTFFT EIGIGILANS FLLLFHIFKF IRGQRSRLTD LPIGLLSLIH LLMLLMGAFI AIDIFISWRG WDDIICKFLV YLYRSFRGLS LCTTCMLSVL QAITLSPRSS CLAKFKHKSP HHVSCAIISL SILYMFISSH LLVSINATPN LTTNNFMQVT QSCYIIPLSY LMQSMFSTLL AIRDISLISL MVLSTCYMVV LLCRHRNQIQ HLQGTNLSPK ASPEQRATQT ILMLMTFFVL MSIFDSIVSC SRTMYLNDPT SYYIQIFVVY IYATVSPFVF MSTEKHIVNF LKSMCVRVKN V //