ID   A6I4Z8_RAT              Unreviewed;       116 AA.
AC   A6I4Z8;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   27-NOV-2024, entry version 9.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial {ECO:0000256|ARBA:ARBA00014517, ECO:0000256|PIRNR:PIRNR016564};
GN   Name=Ndufs6 {ECO:0000313|RGD:1584802};
GN   ORFNames=rCG_44483 {ECO:0000313|EMBL:EDM10106.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:EDM10106.1};
RN   [1] {ECO:0000313|EMBL:EDM10106.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM10106.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [2] {ECO:0000313|EMBL:EDM10106.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM10106.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
RA   Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
RA   Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR016564}.
CC   -!- SUBUNIT: Mammalian complex I is composed of 45 different subunits. This
CC       is a component of the iron-sulfur (IP) fragment of the enzyme.
CC       {ECO:0000256|ARBA:ARBA00011261}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004443}; Matrix side
CC       {ECO:0000256|ARBA:ARBA00004443}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family.
CC       {ECO:0000256|ARBA:ARBA00007291, ECO:0000256|PIRNR:PIRNR016564}.
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DR   EMBL; CH473955; EDM10106.1; -; Genomic_DNA.
DR   AGR; RGD:1584802; -.
DR   RGD; 1584802; Ndufs6.
DR   Proteomes; UP000234681; Chromosome 2.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0045271; C:respiratory chain complex I; ISO:RGD.
DR   GO; GO:0090398; P:cellular senescence; ISO:RGD.
DR   GO; GO:0072359; P:circulatory system development; ISO:RGD.
DR   GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISO:RGD.
DR   GO; GO:0006631; P:fatty acid metabolic process; ISO:RGD.
DR   GO; GO:0010467; P:gene expression; ISO:RGD.
DR   GO; GO:0001822; P:kidney development; ISO:RGD.
DR   GO; GO:0072497; P:mesenchymal stem cell differentiation; ISO:RGD.
DR   GO; GO:0097168; P:mesenchymal stem cell proliferation; ISO:RGD.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:RGD.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
DR   GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR   GO; GO:0006936; P:muscle contraction; ISO:RGD.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD.
DR   GO; GO:0042391; P:regulation of membrane potential; ISO:RGD.
DR   GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISO:RGD.
DR   GO; GO:0061458; P:reproductive system development; ISO:RGD.
DR   GO; GO:0022904; P:respiratory electron transport chain; ISO:RGD.
DR   GO; GO:0017145; P:stem cell division; ISO:RGD.
DR   FunFam; 2.60.260.40:FF:000002; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; 1.
DR   Gene3D; 2.60.260.40; q5lls5 like domains; 1.
DR   InterPro; IPR016668; NDUFS6.
DR   InterPro; IPR019401; Znf_CHCC.
DR   PANTHER; PTHR13156:SF0; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13156; NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT; 1.
DR   Pfam; PF10276; zf-CHCC; 1.
DR   PIRSF; PIRSF016564; CI-13KD-A; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|PIRNR:PIRNR016564};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR016564};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|PIRNR:PIRNR016564};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW   ECO:0000256|PIRNR:PIRNR016564};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW   ECO:0000256|PIRNR:PIRNR016564};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR016564}.
FT   DOMAIN          75..111
FT                   /note="Zinc finger CHCC-type"
FT                   /evidence="ECO:0000259|Pfam:PF10276"
SQ   SEQUENCE   116 AA;  12797 MW;  32BD96137877F25C CRC64;
     MVAALTFRRL LALPRAARGF GVRVSLSGEK ITHTGQVSDG KDYRGIRFVD RQKEVNENFA
     IDLIAQQPVN EVDRRIIACD GGGGALGHPK VYINLDKETK TGTCGYCGLQ FKQQHH
//