ID A6I4Z8_RAT Unreviewed; 116 AA. AC A6I4Z8; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 02-OCT-2024, entry version 8. DE RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial {ECO:0000256|ARBA:ARBA00014517, ECO:0000256|PIRNR:PIRNR016564}; GN Name=Ndufs6 {ECO:0000313|RGD:1584802}; GN ORFNames=rCG_44483 {ECO:0000313|EMBL:EDM10106.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:EDM10106.1}; RN [1] {ECO:0000313|EMBL:EDM10106.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDM10106.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [2] {ECO:0000313|EMBL:EDM10106.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDM10106.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I), that is believed not to be CC involved in catalysis. Complex I functions in the transfer of electrons CC from NADH to the respiratory chain. The immediate electron acceptor for CC the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR016564}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|ARBA:ARBA00004443}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004443}; Matrix side CC {ECO:0000256|ARBA:ARBA00004443}. CC -!- SIMILARITY: Belongs to the complex I NDUFS6 subunit family. CC {ECO:0000256|ARBA:ARBA00007291, ECO:0000256|PIRNR:PIRNR016564}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH473955; EDM10106.1; -; Genomic_DNA. DR AGR; RGD:1584802; -. DR RGD; 1584802; Ndufs6. DR Proteomes; UP000234681; Chromosome 2. DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:RGD. DR GO; GO:0005739; C:mitochondrion; ISO:RGD. DR GO; GO:0090398; P:cellular senescence; ISO:RGD. DR GO; GO:0072359; P:circulatory system development; ISO:RGD. DR GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISO:RGD. DR GO; GO:0006631; P:fatty acid metabolic process; ISO:RGD. DR GO; GO:0001822; P:kidney development; ISO:RGD. DR GO; GO:0072497; P:mesenchymal stem cell differentiation; ISO:RGD. DR GO; GO:0097168; P:mesenchymal stem cell proliferation; ISO:RGD. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISO:RGD. DR GO; GO:0007005; P:mitochondrion organization; ISO:RGD. DR GO; GO:0035264; P:multicellular organism growth; ISO:RGD. DR GO; GO:0006936; P:muscle contraction; ISO:RGD. DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD. DR GO; GO:0042391; P:regulation of membrane potential; ISO:RGD. DR GO; GO:0061458; P:reproductive system development; ISO:RGD. DR GO; GO:0022904; P:respiratory electron transport chain; ISO:RGD. DR GO; GO:0017145; P:stem cell division; ISO:RGD. DR Gene3D; 2.60.260.40; q5lls5 like domains; 1. DR InterPro; IPR016668; NDUFS6. DR InterPro; IPR019401; Znf_CHCC. DR PANTHER; PTHR13156:SF0; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL; 1. DR PANTHER; PTHR13156; NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT; 1. DR Pfam; PF10276; zf-CHCC; 1. DR PIRSF; PIRSF016564; CI-13KD-A; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982, KW ECO:0000256|PIRNR:PIRNR016564}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR016564}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|PIRNR:PIRNR016564}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|PIRNR:PIRNR016564}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660, KW ECO:0000256|PIRNR:PIRNR016564}; KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR016564}. FT DOMAIN 75..111 FT /note="Zinc finger CHCC-type" FT /evidence="ECO:0000259|Pfam:PF10276" SQ SEQUENCE 116 AA; 12797 MW; 32BD96137877F25C CRC64; MVAALTFRRL LALPRAARGF GVRVSLSGEK ITHTGQVSDG KDYRGIRFVD RQKEVNENFA IDLIAQQPVN EVDRRIIACD GGGGALGHPK VYINLDKETK TGTCGYCGLQ FKQQHH //