ID A6I104_RAT Unreviewed; 419 AA. AC A6I104; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 13-SEP-2023, entry version 2. DE SubName: Full=Transmembrane protein 23, isoform CRA_a {ECO:0000313|EMBL:EDM13135.1}; GN Name=Tmem23 {ECO:0000313|EMBL:EDM13135.1}; GN ORFNames=rCG_47229 {ECO:0000313|EMBL:EDM13135.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:EDM13135.1, ECO:0000313|Proteomes:UP000234681}; RN [1] {ECO:0000313|Proteomes:UP000234681} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BN, Sprague-Dawley {ECO:0000313|Proteomes:UP000234681}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family. CC {ECO:0000256|ARBA:ARBA00005441}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH473953; EDM13135.1; -; Genomic_DNA. DR RefSeq; NP_852051.2; NM_181386.2. DR GeneID; 353229; -. DR Proteomes; UP000234681; Chromosome 1. DR CDD; cd01610; PAP2_like; 1. DR CDD; cd09514; SAM_SGMS1; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1. DR InterPro; IPR001660; SAM. DR InterPro; IPR013761; SAM/pointed_sf. DR InterPro; IPR045221; Sphingomyelin_synth-like. DR InterPro; IPR025749; Sphingomyelin_synth-like_dom. DR PANTHER; PTHR21290:SF28; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1. DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1. DR Pfam; PF14360; PAP2_C; 1. DR SUPFAM; SSF47769; SAM/Pointed domain; 1. DR PROSITE; PS50105; SAM_DOMAIN; 1. PE 3: Inferred from homology; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 141..162 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 188..209 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 221..239 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 286..302 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 311..331 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 337..353 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 13..76 FT /note="SAM" FT /evidence="ECO:0000259|PROSITE:PS50105" SQ SEQUENCE 419 AA; 49014 MW; CD1E73E61BA6F141 CRC64; MLSASTMKEV VYWSPKKVAD WLLENAMPEY CEPLGHFTGQ DLINLTQEDF TKPPLCRVSS DNGQRLLDMI ETLKMEHHIE AHKNGHANGH LSIGVDIPNP DGSFSIKIKP NGMPNGFRKE MIKIPMPEPE RSQYPMEWGK TLLAFLYALS CFVLTTVMIS VVHERVPPKE VQPPLPDTFF DHFNRVQWAF SICEINGMIL VGLWLFQWLL LKYKSIISRR FFCIVGTLYL YRCITMYVTT LPVPGMHFNC SPKLFGDWEA QVRRIMKLIA GGGLSITGSH NMCGDYLYSG HTVMLTLTYL FIKEYSPRRL WWYHWICWLL SVVGIFCILL AHDHYTVDVV VAYYITTRLF WWYHTMANQQ VLKEASQMNL LARVWWYRPF QYFEKNVQGI VPRSYHWPLP WPVVHLSRQV KYSRLVNDT //