ID A6H5V4_MOUSE Unreviewed; 370 AA. AC A6H5V4; DT 24-JUL-2007, integrated into UniProtKB/TrEMBL. DT 24-JUL-2007, sequence version 1. DT 03-OCT-2012, entry version 45. DE SubName: Full=Mesoderm posterior 2; DE SubName: Full=Mesoderm posterior protein 2; GN Name=Mesp2; ORFNames=mCG_19460; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RX MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [5] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC109221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC145652; AAI45653.1; -; mRNA. DR EMBL; BC145654; AAI45655.1; -; mRNA. DR EMBL; CH466543; EDL07045.1; -; Genomic_DNA. DR IPI; IPI00875262; -. DR RefSeq; NP_032615.2; NM_008589.2. DR UniGene; Mm.31472; -. DR SMR; A6H5V4; 79-138. DR STRING; A6H5V4; -. DR Ensembl; ENSMUST00000107394; ENSMUSP00000103017; ENSMUSG00000030543. DR GeneID; 17293; -. DR KEGG; mmu:17293; -. DR UCSC; uc009hzc.1; mouse. DR CTD; 145873; -. DR MGI; MGI:1096325; Mesp2. DR GeneTree; ENSGT00530000063712; -. DR HOGENOM; HOG000290634; -. DR HOVERGEN; HBG096371; -. DR InParanoid; A6H5V4; -. DR KO; K09076; -. DR OMA; CWSHSAE; -. DR OrthoDB; EOG4J3WJP; -. DR NextBio; 291818; -. DR Genevestigator; A6H5V4; -. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI. DR GO; GO:0008078; P:mesodermal cell migration; IGI:MGI. DR GO; GO:0007219; P:Notch signaling pathway; IGI:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI. DR GO; GO:0001756; P:somitogenesis; IMP:MGI. DR Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1. DR InterPro; IPR011598; HLH_dom. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH_basic; 1. DR PROSITE; PS50888; HLH; 1. PE 2: Evidence at transcript level; KW Complete proteome; Reference proteome. SQ SEQUENCE 370 AA; 39836 MW; BF48437113680033 CRC64; MAQSPPPQSL QGLDHWVFSQ GWGWAQQSDS TSPASSSDSS GSCPCYATRR PSQPAGPARS TRTTQATAPR RTRPAPAGGQ RQSASEREKL RMRTLARALQ ELRRFLPPSV APAGQSLTKI ETLRLAIRYI GHLSALLGLS EDSLRRRRRR SADAAFSHRC PQCPDGGSPS QAQMLGPSLG SAMSSGVSWG CPPACPGPLI SPENLGNRIS NVDPWVTPPY CPQIQSPLHQ SLERAADSSP WAPPQACPGM QMSPEPRNKT GHWTQSTEPA ELTKVYQSLS VSPEPCLSLG SPLLLPRPSC QRLQPQPQPQ PQWGCWGHDA EVLSTSEDQG SSPALQLPVA SPTPSSGLQL SGCPELWQED LEGPPLNIFY //