ID   A5V511_SPHWW            Unreviewed;       509 AA.
AC   A5V511;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   17-JUN-2020, entry version 81.
DE   SubName: Full=Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABQ67377.1};
GN   OrderedLocusNames=Swit_1010 {ECO:0000313|EMBL:ABQ67377.1};
OS   Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=392499 {ECO:0000313|EMBL:ABQ67377.1, ECO:0000313|Proteomes:UP000001989};
RN   [1] {ECO:0000313|Proteomes:UP000001989}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RW1 / DSM 6014 / JCM 10273 {ECO:0000313|Proteomes:UP000001989};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Sphingomonas wittichii RW1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABQ67377.1, ECO:0000313|Proteomes:UP000001989}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RW1 / DSM 6014 / JCM 10273 {ECO:0000313|Proteomes:UP000001989};
RX   PubMed=20833805; DOI=10.1128/JB.01030-10;
RA   Miller T.R., Delcher A.L., Salzberg S.L., Saunders E., Detter J.C.,
RA   Halden R.U.;
RT   "Genome sequence of the dioxin-mineralizing bacterium Sphingomonas
RT   wittichii RW1.";
RL   J. Bacteriol. 192:6101-6102(2010).
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; CP000699; ABQ67377.1; -; Genomic_DNA.
DR   RefSeq; WP_011951855.1; NC_009511.1.
DR   STRING; 392499.Swit_1010; -.
DR   PRIDE; A5V511; -.
DR   EnsemblBacteria; ABQ67377; ABQ67377; Swit_1010.
DR   KEGG; swi:Swit_1010; -.
DR   eggNOG; ENOG4107VYJ; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   HOGENOM; CLU_009834_16_3_5; -.
DR   KO; K07516; -.
DR   OMA; ILMKARQ; -.
DR   OrthoDB; 1498685at2; -.
DR   BioCyc; SWIT392499:GHZK-1020-MONOMER; -.
DR   Proteomes; UP000001989; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:ABQ67377.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001989}.
FT   DOMAIN          337..398
FT                   /note="3HCDH_N"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
SQ   SEQUENCE   509 AA;  52443 MW;  3CE6ADF7D19B356F CRC64;
     MAETLVPAVV SDTVRDGIAL IVADSPPVNA LGFAVRSGLH EALGRAIAAD AVEAIVIACD
     GRTFFAGADI AEFAGLIPEP GLNRIYARMD ASPKPIVAAI HGTALGGGLE LALACHYRVA
     AADAKLGLPE VQLGLLPGAG GTQRTPRLIG VAAALELMIS GQPVDAARAK AIGLVDDVAG
     GDLREAAIAL ARRVTAEGTP RRTRDRSPDV TGDAAEALFA RFRADHEAVF TGFKAPGHIL
     RAIEASTRLP FDEGRAVEQA LFEELMESHE SLAQRHIFFA ERAAAKVPGL GRDVRPLANP
     SVAVLGEDER ADALRNALAL PSAPEGEADL IVIADPAIEV DAVAARAARP EAVVALHLPI
     EVAGNRLLEI GRGTRTSDVA LATALALARR LGRAPVVSAG TAGLIGTRVL AAGRVAAEAL
     VGEGISASAI DRAMTGYGFP SGLFGPAVGE AVDDAAIVRR LLAAMVEESA RIVEQGVAPR
     ASDVDVAMVL GFGWPAWRGG PLFRAERAT
//