ID TRUD_HAEIE Reviewed; 339 AA. AC A5UE25; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 10-JUL-2007, sequence version 1. DT 19-JAN-2010, entry version 25. DE RecName: Full=tRNA pseudouridine synthase D; DE EC=5.4.99.-; DE AltName: Full=tRNA-uridine isomerase D; DE AltName: Full=tRNA pseudouridylate synthase D; GN Name=truD; OrderedLocusNames=CGSHiEE_08635; OS Haemophilus influenzae (strain PittEE). OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Haemophilus. OX NCBI_TaxID=374930; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103; RA Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., RA Post J.C., Ehrlich G.D.; RT "Characterization and modeling of the Haemophilus influenzae core and RT supragenomes based on the complete genomic sequences of Rd and 12 RT clinical nontypeable strains."; RL Genome Biol. 8:R103.1-R103.18(2007). CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil- CC 13 in transfer RNAs (By similarity). CC -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine. CC -!- SIMILARITY: Belongs to the pseudouridine synthase truD family. CC -!- SIMILARITY: Contains 1 TRUD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000671; ABQ99026.1; -; Genomic_DNA. DR RefSeq; YP_001291409.1; -. DR SMR; A5UE25; 2-335. DR STRING; A5UE25; -. DR GeneID; 5225462; -. DR GenomeReviews; CP000671_GR; CGSHiEE_08635. DR KEGG; hip:CGSHiEE_08635; -. DR eggNOG; COG0585; -. DR HOGENOM; HBG541221; -. DR OMA; ALTRQWF; -. DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP. DR HAMAP; MF_01082; TruD; 1; -. DR InterPro; IPR020103; PsdUridine_synth_cat_dom. DR InterPro; IPR001656; PsdUridine_synth_TruD. DR InterPro; IPR020119; PsdUridine_synth_TruD_CS. DR InterPro; IPR011760; PsdUridine_synth_TruD_insert. DR PANTHER; PTHR13326; PsU_synth_TruD; 1. DR Pfam; PF01142; TruD; 1. DR PROSITE; PS50984; TRUD; 1. DR PROSITE; PS01268; UPF0024; 1. PE 3: Inferred from homology; KW Complete proteome; Isomerase; tRNA processing. FT CHAIN 1 339 tRNA pseudouridine synthase D. FT /FTId=PRO_1000084742. FT DOMAIN 155 311 TRUD. FT ACT_SITE 80 80 Nucleophile (By similarity). SQ SEQUENCE 339 AA; 38503 MW; 9C5393F3F01CA3A2 CRC64; MLEQLPYLAL KTPPKTTALL KAECADFIVK EHLGYEMSGD GEFVALYVRK TDCNTLFVGE KLAKFAGVSE RNMGYAGLKD RRAVTEQWFC LQMPGMETPD FSQFELDGVE ILTVTRHNRK IRTGSLEGNY FDILLRGAEE SDELKVRLDF VANFGFPNYF TEQRFGREGH NLTQALRWAQ GEIKVKDRKK RSFYLSAARS EIFNLVVAAR IAKGATNQVL PNDIVQLAGS HSWFKADEKE DLNALQVRLE NQDILLTAPL IGEDILAASD IENEIVNQHS VFDPLMKQER MKAARRPLLM KAKGFSWAFE LEGLRLKFYL PAGSYATALV RELVNYTEE //