ID A5IAU5_LEGPC Unreviewed; 483 AA. AC A5IAU5; DT 26-JUN-2007, integrated into UniProtKB/TrEMBL. DT 26-JUN-2007, sequence version 1. DT 08-APR-2008, entry version 12. DE Aminopeptidase A/I. GN Name=pepA; OrderedLocusNames=LPC_0510; OS Legionella pneumophila (strain Corby). OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; OC Legionellaceae; Legionella. OX NCBI_TaxID=400673; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., RA Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.; RT "Identification and characterization of a new conjugation/ type IVA RT secretion system (trb/tra) of L. pneumophila Corby localized on a RT mobile genomic island."; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Release of an N-terminal amino acid, Xaa-|- CC Yaa-, in which Xaa is preferably Leu, but may be other amino acids CC including Pro although not Arg or Lys, and Yaa may be Pro. Amino CC acid amides and methyl esters are also readily hydrolyzed, but CC rates on arylamides are exceedingly low. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000675; ABQ54495.1; -; Genomic_DNA. DR RefSeq; YP_001249841.1; -. DR MEROPS; M17.003; -. DR GeneID; 5182305; -. DR GenomeReviews; CP000675_GR; LPC_0510. DR KEGG; lpc:LPC_0510; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004178; F:leucyl aminopeptidase activity; IEA:InterPro. DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR InterPro; IPR011356; Peptidase_M17. DR InterPro; IPR000819; Peptidase_M17_C. DR InterPro; IPR008283; Peptidase_M17_N. DR PANTHER; PTHR11963:SF3; Peptidase_M17; 1. DR Pfam; PF00883; Peptidase_M17; 1. DR Pfam; PF02789; Peptidase_M17_N; 1. DR PRINTS; PR00481; LAMNOPPTDASE. DR PROSITE; PS00631; CYTOSOL_AP; 1. PE 4: Predicted; KW Aminopeptidase; Complete proteome; Hydrolase; Metal-binding; Protease. SQ SEQUENCE 483 AA; 52613 MW; 695CC2F46D38ACE6 CRC64; MNYGLTHTPS LTMSECLVLG VFSDLALPDF ATAIDNEQKG LIKKLCQRVP EPGNTVWQTD VEGHSLLIIQ CGKKEEFSAN SLQKRVGEIT EALIKQRFSS ATVCLPRLNQ ESAEWQLEQM IVQIDNLRYQ LLDFKTKHAK SHKLESVIFH LPGATEKSLE MAKAIVTGVE FCRDLANMPA NICTPTYLGE QAISLSKQFD QISCQVMGPE EIKEMGMGAL LAVAQGSDQP PRLIDIHYHG NKNSTPVILV GKGITFDSGG LSIKPANAMD EMKYDMSGAA SVLGVIKACA LLKLPINLIG IIASAENLIS GSAVKSGDIV TTMSGQTVEI INTDAEGRLV LADALTYAER YNPDFVIDIA TLTGAIIVAL GNIATGYMTR DEQLAKSIER AANESQDKVW RMPLDEAYQD ALESPLADMI NAGFDRSAGS ITAACFLSRF TEKYRWAHLD IAGTAWISGK KRNATGRPVP LLIQLLRHVA NSR //