ID A5EY22_DICNV Unreviewed; 478 AA. AC A5EY22; DT 12-JUN-2007, integrated into UniProtKB/TrEMBL. DT 12-JUN-2007, sequence version 1. DT 15-JAN-2008, entry version 7. DE UDP-N-acetylmuramate-alanine ligase (EC 6.3.2.8). GN Name=murC; OrderedLocusNames=DNO_0980; OS Dichelobacter nodosus (strain VCS1703A). OC Bacteria; Proteobacteria; Gammaproteobacteria; Cardiobacteriales; OC Cardiobacteriaceae; Dichelobacter. OX NCBI_TaxID=246195; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17468768; DOI=10.1038/nbt1302; RA Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., RA Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., RA Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., RA Holley T., Fedorova N., Khouri H., Bottomley S.P., Whittington R.J., RA Adler B., Songer J.G., Rood J.I., Paulsen I.T.; RT "Genome sequence and identification of candidate vaccine antigens from RT the animal pathogen Dichelobacter nodosus."; RL Nat. Biotechnol. 25:569-575(2007). CC -!- FUNCTION: Cell wall formation (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramate + L-alanine = ADP + CC phosphate + UDP-N-acetylmuramoyl-L-alanine. CC -!- PATHWAY: Cell wall biosynthesis; peptidoglycan biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the murCDEF family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000513; ABQ13874.1; -; Genomic_DNA. DR RefSeq; YP_001209869.1; -. DR GeneID; 5123162; -. DR KEGG; dno:DNO_0980; -. DR TIGR; DNO_0980; -. DR InterPro; IPR004101; Mur_ligase_C. DR InterPro; IPR013221; Mur_ligase_cen. DR InterPro; IPR000713; Mur_ligase_N. DR InterPro; IPR005758; UDP-N-AcMur_Ala_ligase. DR Pfam; PF01225; Mur_ligase; 1. DR Pfam; PF02875; Mur_ligase_C; 1. DR Pfam; PF08245; Mur_ligase_M; 1. DR TIGRFAMs; TIGR01082; murC; 1. PE 3: Inferred from homology; KW ATP-binding; Cell cycle; Cell division; Cell shape; KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; KW Ligase; Nucleotide-binding; Peptidoglycan synthesis. SQ SEQUENCE 478 AA; 52470 MW; E34B81D00796B3A5 CRC64; MNHEVHFGRI ERRHMRRVKN IFFVGIGGTG MSGIAEVLLN LGYSISGSDI KDSAVTQYLA QKGAQIFIGH AAENVEHADV VVVSSAIAEN NVEVKQARAL EIPVIRRAQM LAELMRFRFG IAIAGTHGKT TTTSLTASLL SDAGLDPTFV IGGILTAAGS NARLGEGHYL VAESDESDCS FWLLQPMISI VTNIDADHLE NYNGSYETLK AGFVRFLHNL PFYGLAVLCI DDAGVRSILP EVGRPVRTYG FSEDADVRAI NVRQKGLAMH FDVIAHDEDR CFSVTLNMAG KHNVLNALAA IIVGEELGID RETIIEGLAQ FKGVARRFTH HGRIAHDHGF ADVFEDYGHH PREIKAVLDA AMEGFAGRRI VAVFQPHRFT RTRDLLDDFA EVLAVCDCLV LTEVYAAGEE PIAGADARDL TRAIRAHGRV EPIFIADKEE IVPHLRHDIL QDDDVVIFFG AGDIGRVAKM MDELKIKE //