ID A5D6V9_HUMAN Unreviewed; 406 AA. AC A5D6V9; DT 12-JUN-2007, integrated into UniProtKB/TrEMBL. DT 12-JUN-2007, sequence version 1. DT 10-FEB-2021, entry version 86. DE SubName: Full=CDH23 protein {ECO:0000313|EMBL:AAI39904.1}; GN Name=CDH23 {ECO:0000313|EMBL:AAI39904.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI39904.1}; RN [1] {ECO:0000313|EMBL:AAI39904.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC139903; AAI39904.1; -; mRNA. DR RefSeq; NP_001165403.1; NM_001171932.1. DR SMR; A5D6V9; -. DR PeptideAtlas; A5D6V9; -. DR GeneID; 64072; -. DR CTD; 64072; -. DR PharmGKB; PA26296; -. DR BioGRID-ORCS; 64072; 1 hit in 867 CRISPR screens. DR ChiTaRS; CDH23; human. DR GenomeRNAi; 64072; -. DR Genevisible; A5D6V9; HS. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0032420; C:stereocilium; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IEA:InterPro. DR GO; GO:0007626; P:locomotory behavior; IEA:InterPro. DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR033030; CDH23. DR PANTHER; PTHR24025:SF18; PTHR24025:SF18; 2. DR Pfam; PF00028; Cadherin; 3. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 3. DR SUPFAM; SSF49313; SSF49313; 3. DR PROSITE; PS00232; CADHERIN_1; 2. DR PROSITE; PS50268; CADHERIN_2; 3. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE- KW ProRule:PRU00043}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..406 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002679718" FT DOMAIN 42..132 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 133..236 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT DOMAIN 237..348 FT /note="Cadherin" FT /evidence="ECO:0000259|PROSITE:PS50268" FT REGION 385..406 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 388..406 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 406 AA; 44521 MW; 9F34253B38118B81 CRC64; MGRHVATSCH VAWLLVLISG CWGQVNRLPF FTNHFFDTYL LISEDTPVGS SVTQLLAQDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP IFIVNATDPD LGAGGSVLYS FQPPSQFFAI DSARGIVTVI RELDYETTQA YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP YSTNIYEHSP PGTTVRIITA IDQDKGRPRG IGYTIVSGNT NSIFALDYIS GVLTLNGLLD RENPLYSHGF ILTVKGTELN DDRTPSDATV TTTFNILVID INDNAPEFNS SEYSVAITEL AQVGFALPLF IQVVDKDEVS PWTHGPCRPT THPDPPPCLG CSGPQL //