ID A4V922_HRSV Unreviewed; 115 AA. AC A4V922; DT 29-MAY-2007, integrated into UniProtKB/TrEMBL. DT 29-MAY-2007, sequence version 1. DT 07-APR-2021, entry version 31. DE RecName: Full=Major surface glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE AltName: Full=Attachment glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE Flags: Fragment; GN Name=G {ECO:0000256|RuleBase:RU363027, ECO:0000313|EMBL:CAL64794.1}; OS Human respiratory syncytial virus (strain RSP140/Sweden/02-03). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus. OX NCBI_TaxID=410248 {ECO:0000313|EMBL:CAL64794.1}; RN [1] {ECO:0000313|EMBL:CAL64794.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RSP140/Sweden/02-03 {ECO:0000313|EMBL:CAL64794.1}; RX PubMed=18041002; DOI=10.1002/jmv.21066; RA Rotzen Ostlund M., Tiveljung Lindell A., Stenler S., Riedel H.M., RA Zweygberg Wirgart B., Grillner L.; RT "Molecular Epidemiology and Genetic Variability of Respiratory Syncytial RT Virus (RSV) in Stockholm, 2002-2003."; RL J. Med. Virol. 80:159-167(2008). CC -!- FUNCTION: Helps the virus escape antibody-dependent restriction of CC replication by acting as an antigen decoy and by modulating the CC activity of leukocytes bearing Fc-gamma receptors. CC {ECO:0000256|ARBA:ARBA00023752}. CC -!- FUNCTION: [Isoform Secreted glycoprotein G]: Helps the virus escape CC antibody-dependent restriction of replication by acting as an antigen CC decoy and by modulating the activity of leukocytes bearing Fc-gamma CC receptors. {ECO:0000256|RuleBase:RU363027}. CC -!- SUBUNIT: [Isoform Membrane-bound glycoprotein G]: Homooligomer. CC Interacts (via N-terminus) with protein M. Part of a complex composed CC of F1, F2 and G glycoproteins. Interacts with protein SH. Interacts CC with host heparate sulfate; this interaction probably participates in CC the viral attachment to the host cell. {ECO:0000256|RuleBase:RU363027}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. CC Host cell membrane {ECO:0000256|ARBA:ARBA00004336}; Single-pass type II CC membrane protein {ECO:0000256|ARBA:ARBA00004336}. Membrane CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein CC {ECO:0000256|ARBA:ARBA00004606}. Secreted CC {ECO:0000256|RuleBase:RU363027}. Virion membrane CC {ECO:0000256|RuleBase:RU363027}. CC -!- SIMILARITY: Belongs to the pneumoviruses glycoprotein G family. CC {ECO:0000256|ARBA:ARBA00007101, ECO:0000256|RuleBase:RU363027}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM409217; CAL64794.1; -; Genomic_RNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000925; G_prot. DR Pfam; PF00802; Glycoprotein_G; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363027}; KW Membrane {ECO:0000256|ARBA:ARBA00022870}; KW Secreted {ECO:0000256|RuleBase:RU363027}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363027}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU363027}; KW Virion {ECO:0000256|RuleBase:RU363027}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363027}. FT REGION 41..115 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 41..98 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAL64794.1" FT NON_TER 115 FT /evidence="ECO:0000313|EMBL:CAL64794.1" SQ SEQUENCE 115 AA; 12743 MW; 717C72E8088A823C CRC64; STSLIIAAII FIISANHKVT LTTVTVQTIK NHTEKNITTY FTQVSPERVS PSKQPTTTPP IHTNSATISP NTKSETHHTT AQTKSRTTTP TQNNKPSTKP RPKNPPKKPK DDYHF //