ID A4V922_HRSV Unreviewed; 115 AA. AC A4V922; DT 29-MAY-2007, integrated into UniProtKB/TrEMBL. DT 29-MAY-2007, sequence version 1. DT 18-JUL-2018, entry version 22. DE RecName: Full=Major surface glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE AltName: Full=Attachment glycoprotein G {ECO:0000256|RuleBase:RU363027}; DE Flags: Fragment; GN Name=G {ECO:0000256|RuleBase:RU363027, ECO:0000313|EMBL:CAL64794.1}; OS Human respiratory syncytial virus (strain RSP140/Sweden/02-03). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Mononegavirales; Pneumoviridae; Orthopneumovirus. OX NCBI_TaxID=410248 {ECO:0000313|EMBL:CAL64794.1}; RN [1] {ECO:0000313|EMBL:CAL64794.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RSP140/Sweden/02-03 {ECO:0000313|EMBL:CAL64794.1}; RX PubMed=18041002; DOI=10.1002/jmv.21066; RA Rotzen Ostlund M., Tiveljung Lindell A., Stenler S., Riedel H.M., RA Zweygberg Wirgart B., Grillner L.; RT "Molecular Epidemiology and Genetic Variability of Respiratory RT Syncytial Virus (RSV) in Stockholm, 2002-2003."; RL J. Med. Virol. 80:159-167(2008). CC -!- FUNCTION: Attaches the virion to the host cell membrane by CC interacting with heparan sulfate, initiating the infection. CC Interacts with host CX3CR1, the receptor for the CX3C chemokine CC fractalkine, to modulate the immune response and facilitate CC infection. Unlike the other paramyxovirus attachment proteins, CC lacks both neuraminidase and hemagglutinating activities. CC {ECO:0000256|RuleBase:RU363027}. CC -!- FUNCTION: Secreted glycoprotein G helps RSV escape antibody- CC dependent restriction of replication by acting as an antigen decoy CC and by modulating the activity of leukocytes bearing Fcgamma CC receptors. {ECO:0000256|RuleBase:RU363027}. CC -!- SUBUNIT: Homooligomer. Interacts (via N-terminus) with protein M. CC Interacts with protein F; this interaction occurs on the surface CC of infected cells. Interacts with protein SH. Interacts with host CC CX3CR1; this interaction modulates host immune response. CC {ECO:0000256|RuleBase:RU363027}. CC -!- SUBCELLULAR LOCATION: Host cell surface CC {ECO:0000256|RuleBase:RU363027}. Secreted CC {ECO:0000256|RuleBase:RU363027}. Virion membrane CC {ECO:0000256|RuleBase:RU363027}. CC -!- SIMILARITY: Belongs to the pneumoviruses glycoprotein G family. CC {ECO:0000256|RuleBase:RU363027}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM409217; CAL64794.1; -; Genomic_RNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000925; G_prot. DR Pfam; PF00802; Glycoprotein_G; 1. PE 3: Inferred from homology; KW Host-virus interaction {ECO:0000256|RuleBase:RU363027}; KW Secreted {ECO:0000256|RuleBase:RU363027}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363027}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU363027}; KW Virion {ECO:0000256|RuleBase:RU363027}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363027}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAL64794.1}. FT NON_TER 115 115 {ECO:0000313|EMBL:CAL64794.1}. SQ SEQUENCE 115 AA; 12743 MW; 717C72E8088A823C CRC64; STSLIIAAII FIISANHKVT LTTVTVQTIK NHTEKNITTY FTQVSPERVS PSKQPTTTPP IHTNSATISP NTKSETHHTT AQTKSRTTTP TQNNKPSTKP RPKNPPKKPK DDYHF //