ID A4V0S1_DROME Unreviewed; 467 AA. AC A4V0S1; DT 29-MAY-2007, integrated into UniProtKB/TrEMBL. DT 29-MAY-2007, sequence version 1. DT 03-MAY-2023, entry version 122. DE SubName: Full=Syntaxin 5, isoform B {ECO:0000313|EMBL:AAN10935.1}; GN Name=Syx5 {ECO:0000313|EMBL:AAN10935.1, GN ECO:0000313|FlyBase:FBgn0011708}; GN Synonyms=anon-35Fb {ECO:0000313|EMBL:AAN10935.1}, anon-35Fd GN {ECO:0000313|EMBL:AAN10935.1}, BG:DS02740.12 GN {ECO:0000313|EMBL:AAN10935.1}, Dmel\CG4214 GN {ECO:0000313|EMBL:AAN10935.1}, DmSyx5 {ECO:0000313|EMBL:AAN10935.1}, GN dSed5 {ECO:0000313|EMBL:AAN10935.1}, dsed5 GN {ECO:0000313|EMBL:AAN10935.1}, dSed5p {ECO:0000313|EMBL:AAN10935.1}, GN dSyx5 {ECO:0000313|EMBL:AAN10935.1}, II {ECO:0000313|EMBL:AAN10935.1}, GN l(2)35Ff {ECO:0000313|EMBL:AAN10935.1}, SED5 GN {ECO:0000313|EMBL:AAN10935.1}, Sed5 {ECO:0000313|EMBL:AAN10935.1}, GN sed5 {ECO:0000313|EMBL:AAN10935.1}, STX5 GN {ECO:0000313|EMBL:AAN10935.1}, SYN5 {ECO:0000313|EMBL:AAN10935.1}, GN syn5 {ECO:0000313|EMBL:AAN10935.1}, Synx5 GN {ECO:0000313|EMBL:AAN10935.1}, Syx {ECO:0000313|EMBL:AAN10935.1}, syx5 GN {ECO:0000313|EMBL:AAN10935.1}, Syx5A {ECO:0000313|EMBL:AAN10935.1}; GN ORFNames=CG4214 {ECO:0000313|EMBL:AAN10935.1, GN ECO:0000313|FlyBase:FBgn0011708}, Dmel_CG4214 GN {ECO:0000313|EMBL:AAN10935.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAN10935.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the syntaxin family. CC {ECO:0000256|ARBA:ARBA00009063}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAN10935.1; -; Genomic_DNA. DR RefSeq; NP_523582.4; NM_078858.5. DR RefSeq; NP_599132.2; NM_134305.3. DR AlphaFoldDB; A4V0S1; -. DR SMR; A4V0S1; -. DR DNASU; 34966; -. DR EnsemblMetazoa; FBtr0080831; FBpp0080389; FBgn0011708. DR EnsemblMetazoa; FBtr0080832; FBpp0080390; FBgn0011708. DR GeneID; 34966; -. DR KEGG; dme:Dmel_CG4214; -. DR UCSC; CG4214-RB; d. melanogaster. DR AGR; FB:FBgn0011708; -. DR CTD; 34966; -. DR FlyBase; FBgn0011708; Syx5. DR VEuPathDB; VectorBase:FBgn0011708; -. DR HOGENOM; CLU_044998_1_1_1; -. DR OMA; RGITGTM; -. DR OrthoDB; 70739at2759; -. DR PhylomeDB; A4V0S1; -. DR BioGRID-ORCS; 34966; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 34966; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0011708; Expressed in spermathecum and 24 other tissues. DR ExpressionAtlas; A4V0S1; baseline and differential. DR Genevisible; A4V0S1; DM. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro. DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro. DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro. DR CDD; cd15844; SNARE_syntaxin5; 1. DR Gene3D; 1.20.58.70; -; 1. DR InterPro; IPR010989; SNARE. DR InterPro; IPR045242; Syntaxin. DR InterPro; IPR006012; Syntaxin/epimorphin_CS. DR InterPro; IPR000727; T_SNARE_dom. DR PANTHER; PTHR19957; SYNTAXIN; 1. DR PANTHER; PTHR19957:SF3; SYNTAXIN-5; 1. DR Pfam; PF05739; SNARE; 1. DR SMART; SM00397; t_SNARE; 1. DR SUPFAM; SSF47661; t-snare proteins; 1. DR PROSITE; PS00914; SYNTAXIN; 1. DR PROSITE; PS50192; T_SNARE; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE- KW ProRule:PRU00202}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A4V0S1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 446..466 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 375..437 FT /note="T-SNARE coiled-coil homology" FT /evidence="ECO:0000259|PROSITE:PS50192" FT REGION 1..53 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 58..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 310..335 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12..34 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 314..335 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 467 AA; 51850 MW; DE43A6BDA649B0C4 CRC64; MQTRRRLHQT DQQDYSSSST YTIQEDQQGG AGAGSVGTGT AGGSVGLLAQ SLVPPPTGHE AAIHIGDNYQ SGDSISTPDY SDDKYGKAAR QWNLRAFSGH ALRTLSAAAA VVTGNQPGIN NDSQSNYSYP ASIPTSSQFY QSKEEPQETE PEPEIFVMAA RDRTGEFANA IRSLQARNIT RAVNIRDPRK AKQVQSYSEF MMVARFIGKN IASTYAKLEK LTMLAKKKSL FDDRPQEIQE LTYIIKGDLN ALNQQIARLQ DISKDQRRHT NGKHLVSHSS NMVLALQSKL ASMSTDFKQI LEVRTENLKQ QKTRRDQFSQ GPGPLAAHTV SPSTAKQGSL LLSEENQAVS IDMGSSDTTP LLSTQTQMAI YDDSDNYVQQ RAETMQNIES TIVELGGIFQ QLAHMVKEQE EIVERIDTNV ADAELNIEAA HGEILKYFQS VSKNRWLMIK IFGVLIFFFL FFVVFMS //