ID A4UUI2_MOUSE Unreviewed; 589 AA. AC A4UUI2; DT 15-MAY-2007, integrated into UniProtKB/TrEMBL. DT 15-MAY-2007, sequence version 1. DT 25-OCT-2017, entry version 90. DE SubName: Full=Guanylate binding protein 1 {ECO:0000313|EMBL:ABO88215.1}; DE SubName: Full=Guanylate-binding protein 2b {ECO:0000313|Ensembl:ENSMUSP00000029936}; GN Name=Gbp2b {ECO:0000313|Ensembl:ENSMUSP00000029936, GN ECO:0000313|MGI:MGI:95666}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABO88215.1}; RN [1] {ECO:0000313|EMBL:ABO88215.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:ABO88215.1}; RC TISSUE=Liver {ECO:0000313|EMBL:ABO88215.1}; RX PubMed=18025219; RA Degrandi D., Konermann C., Beuter-Gunia C., Kresse A., Wurthner J., RA Kurig S., Beer S., Pfeffer K.; RT "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 RT involved in host defense."; RL J. Immunol. 179:7729-7740(2007). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000029936, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000029936, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000029936} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000029936}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC102108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EF494422; ABO88215.1; -; mRNA. DR RefSeq; NP_034389.2; NM_010259.2. DR UniGene; Mm.457978; -. DR Ensembl; ENSMUST00000029936; ENSMUSP00000029936; ENSMUSG00000040264. DR GeneID; 14468; -. DR KEGG; mmu:14468; -. DR UCSC; uc008rox.1; mouse. DR CTD; 14468; -. DR MGI; MGI:95666; Gbp2b. DR eggNOG; KOG2037; Eukaryota. DR eggNOG; ENOG410XR6Z; LUCA. DR GeneTree; ENSGT00550000074475; -. DR HOVERGEN; HBG001979; -. DR KO; K20899; -. DR OMA; DMPCMEN; -. DR OrthoDB; EOG091G03P3; -. DR TreeFam; TF331602; -. DR Proteomes; UP000000589; Chromosome 3. DR Bgee; ENSMUSG00000040264; -. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR InterPro; IPR030386; G_GB1_RHD3_dom. DR InterPro; IPR003191; Guanylate-bd_C. DR InterPro; IPR036543; Guanylate-bd_C_sf. DR InterPro; IPR015894; Guanylate-bd_N. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF02263; GBP; 1. DR Pfam; PF02841; GBP_C; 1. DR SUPFAM; SSF48340; SSF48340; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS51715; G_GB1_RHD3; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW GTP-binding {ECO:0000256|SAAS:SAAS00494893}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00210749}; KW Proteomics identification {ECO:0000213|MaxQB:A4UUI2, KW ECO:0000213|PeptideAtlas:A4UUI2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 35 276 GB1/RHD3-type G. {ECO:0000259|PROSITE: FT PS51715}. FT COILED 480 553 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 589 AA; 67841 MW; 9E3AC4C5D072C576 CRC64; MASEIHMKGP VCLIKNSGEQ LEVYQEALDI LSAIQNPVVV VAIVGFYHTG KSYLMNKLAG KQKGFSLGST VQSHTKGIWM WCMPHPEKPE HTLVLLDTEG LKDMQKGDNQ NDCWIFALAV LLSSTFIYNS IGTINQQAMD QLHYVTELTD LIKSKSSPDQ SDVDNSANFV GFFPIFVWTL RDFSLDLEFD GESITPDEYL ETSLALRKGT DENTKKFNMP RLCIRKFFPK RKCFIFDRPG DRKQLSKLEW IQEDQLNKEF VEQVAEFTSY IFSYSGVKTL SGGITVNGPR LKSLVQTYVS AICSGELPCM ENAVLTLAQI ENSAAVQKAI TYYEEQMNQK IHMPTETLQE LLDLHRTCER EAIEVFMKNS FKDVDQKFQE ELGAQLEAKR DAFVKKNMDM SSAHCSDLLE GLFAHLEEEV KQGTFYKPGG YYLFLQRKQE LEKKYIQTPG KGLQAEVMLR KYFESKEDLA DTLLKMDQSL TEKEKQIEME RIKAEAAEAA NRALAEMQKK HEMLMEQKEQ SYQEHMKQLT EKMEQERKEL MAEQQRIISL KLQEQERLLK QGFQNESLQL RQEIEKIKNM PPPRSCTIL //