ID A4UUI2_MOUSE Unreviewed; 589 AA. AC A4UUI2; DT 15-MAY-2007, integrated into UniProtKB/TrEMBL. DT 15-MAY-2007, sequence version 1. DT 03-OCT-2012, entry version 41. DE SubName: Full=Guanylate binding protein 1; DE SubName: Full=Interferon-induced guanylate-binding protein 1; GN Name=Gbp1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6; TISSUE=Liver; RX PubMed=18025219; RA Degrandi D., Konermann C., Beuter-Gunia C., Kresse A., Wurthner J., RA Kurig S., Beer S., Pfeffer K.; RT "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 RT involved in host defense."; RL J. Immunol. 179:7729-7740(2007). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC102108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; EF494422; ABO88215.1; -; mRNA. DR IPI; IPI00845811; -. DR RefSeq; NP_034389.2; NM_010259.2. DR UniGene; Mm.457978; -. DR SMR; A4UUI2; 2-578. DR STRING; A4UUI2; -. DR Ensembl; ENSMUST00000029936; ENSMUSP00000029936; ENSMUSG00000028269. DR GeneID; 14468; -. DR KEGG; mmu:14468; -. DR UCSC; uc008rox.1; mouse. DR CTD; 2633; -. DR MGI; MGI:95666; Gbp1. DR GeneTree; ENSGT00550000074475; -. DR HOVERGEN; HBG001979; -. DR InParanoid; A4UUI2; -. DR OMA; RANEKEA; -. DR NextBio; 286126; -. DR Genevestigator; A4UUI2; -. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI. DR GO; GO:0020005; C:symbiont-containing vacuole membrane; IDA:MGI. DR GO; GO:0019002; F:GMP binding; IDA:MGI. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0051856; P:adhesion to symbiont; IDA:MGI. DR GO; GO:0035458; P:cellular response to interferon-beta; IDA:MGI. DR GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:MGI. DR GO; GO:0042832; P:defense response to protozoan; IDA:MGI. DR GO; GO:0006184; P:GTP catabolic process; IEA:GOC. DR Gene3D; G3DSA:1.20.1000.10; Guanylate-bd_C; 1. DR InterPro; IPR003191; Guanylate-bd_C. DR InterPro; IPR015894; Guanylate-bd_N. DR Pfam; PF02263; GBP; 1. DR Pfam; PF02841; GBP_C; 1. DR SUPFAM; SSF48340; GBP; 1. PE 2: Evidence at transcript level; KW Complete proteome; Reference proteome. SQ SEQUENCE 589 AA; 67841 MW; 9E3AC4C5D072C576 CRC64; MASEIHMKGP VCLIKNSGEQ LEVYQEALDI LSAIQNPVVV VAIVGFYHTG KSYLMNKLAG KQKGFSLGST VQSHTKGIWM WCMPHPEKPE HTLVLLDTEG LKDMQKGDNQ NDCWIFALAV LLSSTFIYNS IGTINQQAMD QLHYVTELTD LIKSKSSPDQ SDVDNSANFV GFFPIFVWTL RDFSLDLEFD GESITPDEYL ETSLALRKGT DENTKKFNMP RLCIRKFFPK RKCFIFDRPG DRKQLSKLEW IQEDQLNKEF VEQVAEFTSY IFSYSGVKTL SGGITVNGPR LKSLVQTYVS AICSGELPCM ENAVLTLAQI ENSAAVQKAI TYYEEQMNQK IHMPTETLQE LLDLHRTCER EAIEVFMKNS FKDVDQKFQE ELGAQLEAKR DAFVKKNMDM SSAHCSDLLE GLFAHLEEEV KQGTFYKPGG YYLFLQRKQE LEKKYIQTPG KGLQAEVMLR KYFESKEDLA DTLLKMDQSL TEKEKQIEME RIKAEAAEAA NRALAEMQKK HEMLMEQKEQ SYQEHMKQLT EKMEQERKEL MAEQQRIISL KLQEQERLLK QGFQNESLQL RQEIEKIKNM PPPRSCTIL //