ID A4IW10_FRATW Unreviewed; 843 AA. AC A4IW10; DT 01-MAY-2007, integrated into UniProtKB/TrEMBL. DT 01-MAY-2007, sequence version 1. DT 23-OCT-2007, entry version 8. DE Translation initiation factor IF-2. GN Name=infB; OrderedLocusNames=FTW_0126; OS Francisella tularensis subsp. tularensis (strain WY96-3418). OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; OC Francisellaceae; Francisella. OX NCBI_TaxID=418136; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG BioHealthBase; RA Godbole S., Auerbach R.K., Beckstrom-Sternberg S.M., Brown N., RA Bruce D., Deng Z., Gilna P., Keim P.S., Kubota K., Munk A.C., RA Noronha J., Peterson J., Wagner D.M., Wei X., Wang A., Wang J., RA Zhou Y., Scheuermann R.H., Brettin T.S.; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: One of the essential components for the initiation of CC protein synthesis. Protects formylmethionyl-tRNA from spontaneous CC hydrolysis and promotes its binding to the 30S ribosomal subunits. CC Also involved in the hydrolysis of GTP during the formation of the CC 70S ribosomal complex (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000608; ABO46112.1; -; Genomic_DNA. DR RefSeq; YP_001121232.1; -. DR GeneID; 4959448; -. DR InterPro; IPR015760; aIF-2. DR InterPro; IPR000178; IF2. DR InterPro; IPR006847; IF2_N. DR InterPro; IPR000795; ProtSyn_GTP_bd. DR InterPro; IPR005225; Small_GTP_bd. DR InterPro; IPR004161; Transl_elong_EFTu/EF1A_2. DR PANTHER; PTHR23115:SF41; aIF-2; 1. DR Pfam; PF00009; GTP_EFTU; 1. DR Pfam; PF03144; GTP_EFTU_D2; 2. DR Pfam; PF04760; IF2_N; 2. DR ProDom; PD186100; IF2; 1. DR TIGRFAMs; TIGR00487; IF-2; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. DR PROSITE; PS01176; IF2; 1. PE 3: Inferred from homology; KW Complete proteome; GTP-binding; Initiation factor; Nucleotide-binding; KW Protein biosynthesis. SQ SEQUENCE 843 AA; 92033 MW; D88627DBE77A16F3 CRC64; MAEITVGQLA QQTNKEVDAL LKQLKSFGIE KSSEKDTLTP TEMKTLLEKI NSAKNTATRK KVTSVKLDGK HKINVSVKRK RRVAKKVEQQ ESTTLEQPQE LETMVQEVSQ QVDIVKEQDN IEQIVENKEA VKVQEQRQAE IAKPVIKDSG FKITAMPEIK IEEIVAEDDE GLAASDKQAK KKAAKKVFSE AVNTNTKYKR EEEEKKSKAK KAGGKGFKKA NPRQLSQLAG DLESFDEFGA KKGKLKAPKV KKQEFTKPVE NTVRTVEIHE GITVSELAQK MAVKGAEIVK VLFNMGVMAT INQSLDQDTA ILIVEEMGHK YTLHNENALE EAVTIVDRSS YKKISRAPVV TIMGHVDHGK TSLLDYIRQT RVVAGEAGGI TQHIGAYSVK TDKGSITFLD TPGHEAFTSM RARGAKSTDI VILVVAADDG VMPQTEEAIQ HAKAARVPIV VAVNKIDKPE ADPDKVISEL AQRNVIPESW GGDVMFVNVS AKTGEGVADL LEAVLLQSEV LELEAFAEGL AEGVVIESRL EKGRGPVATV LVQNGNLKQG DNILCGTEYG RVRAMHNDLG KKIKAAGPAT PVEILGLSGV PAAGDEMVVI ENEKKAKELA AQRSQKQKEA KIAQEQSLKL SNMFNNMGKE GEQQVLKIIL KGDVQGSVEA IRESLLKLST DEVKVDIIAS GIGAITSSDV TLAVASTAVV IGFNVRADSA AKKLAETDGV EFRYYNIIYD LIDDVKKAMS GLLSPEMKEQ IIGIAEVREV YRSSKFGSIA GCMVIEGVVK RTNPIRVLRN NVVIYEGTLE SLKRFKDDAS EVKKGLECGI GVKNYNDVRE GDQIEVFEVA KEL //