ID PB1F2_I77AA Reviewed; 57 AA. AC A4GBY6; DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot. DT 17-APR-2007, sequence version 1. DT 29-MAY-2024, entry version 46. DE RecName: Full=Protein PB1-F2 {ECO:0000255|HAMAP-Rule:MF_04064}; GN Name=PB1 {ECO:0000255|HAMAP-Rule:MF_04064}; Synonyms=PB1-F2; OS Influenza A virus (strain A/Brazil/11/1978 H1N1). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus; OC Alphainfluenzavirus influenzae; Influenza A virus. OX NCBI_TaxID=393560; OH NCBI_TaxID=8782; Aves. OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RA Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., RA Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., RA Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y., RA Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.; RT "The NIAID influenza genome sequencing project."; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May play an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC {ECO:0000255|HAMAP-Rule:MF_04064}. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04064}. CC Host cytoplasm, host cytosol {ECO:0000255|HAMAP-Rule:MF_04064}. CC -!- MISCELLANEOUS: Is not encoded in all strains, and seems to be CC dispensable for replication. CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family. CC {ECO:0000255|HAMAP-Rule:MF_04064}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY020299; ABO38074.1; -; Viral_cRNA. DR SMR; A4GBY6; -. DR Proteomes; UP000008025; Genome. DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0039545; P:symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity; ISS:UniProtKB. DR HAMAP; MF_04064; INFV_PB1F2; 1. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Host cytoplasm; Host nucleus. FT CHAIN 1..57 FT /note="Protein PB1-F2" FT /id="PRO_0000373022" FT REGION 1..36 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..21 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 22..36 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 57 AA; 6540 MW; F640088800E69BA2 CRC64; MGQEQGTPWI QSTGHISTQK GEDGQKTPKL EHRNSTRLMG HYQKTMNQVV MPKQIVY //