ID PB1F2_I77AA Reviewed; 57 AA. AC A4GBY6; DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot. DT 17-APR-2007, sequence version 1. DT 02-NOV-2016, entry version 29. DE RecName: Full=Protein PB1-F2; GN Name=PB1-F2; OS Influenza A virus (strain A/Brazil/11/1978 H1N1). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=393560; OH NCBI_TaxID=8782; Aves. OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RA Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., RA Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., RA Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y., RA Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.; RT "The NIAID influenza genome sequencing project."; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC Promotes alteration of mitochondrial morphology, dissipation of CC mitochondrial membrane potential, and cell death. Alternatively, CC inhibits the production of interferon in the infected cell at the CC level of host mitochondrial antiviral signaling MAVS. Its level of CC expression differs greatly depending on which cell type is CC infected, in a manner that is independent of the levels of CC expression of other viral proteins. Monocytic cells are more CC affected than epithelial cells. Seems to disable virus-infected CC monocytes or other host innate immune cells. May also act in CC trans: extracellular PB1-F2 released by infected cells could CC potentially inactivate hosts cell recruitment to the site of CC infection. During early stage of infection, may predispose the CC mitochondria to permeability transition through interaction with CC human SLC25A6/ANT3 and VDAC1. These proteins participate in the CC formation of the permeability transition pore complex (PTPC) CC responsible of the release of mitochondrial products that triggers CC apoptosis (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane. Host CC nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial CC membrane in most cells types. Otherwise is detected in the nucleus CC and cytosol (By similarity). {ECO:0000250}. CC -!- MISCELLANEOUS: Is not encoded in all strains, and seems to be CC dispensable for replication. CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY020299; ABO38074.1; -; Viral_cRNA. DR Proteomes; UP000008025; Genome. DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; ISS:UniProtKB. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis; Complete proteome; Host cytoplasm; Host membrane; KW Host mitochondrion; Host mitochondrion inner membrane; Host nucleus; KW Host-virus interaction; KW Inhibition of host innate immune response by virus; KW Inhibition of host MAVS by virus; KW Inhibition of host RLR pathway by virus; Membrane; KW Modulation of host cell apoptosis by virus; Viral immunoevasion. FT CHAIN 1 57 Protein PB1-F2. FT /FTId=PRO_0000373022. SQ SEQUENCE 57 AA; 6540 MW; F640088800E69BA2 CRC64; MGQEQGTPWI QSTGHISTQK GEDGQKTPKL EHRNSTRLMG HYQKTMNQVV MPKQIVY //