ID PA_I77AA Reviewed; 716 AA. AC A4GBY4; DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot. DT 17-APR-2007, sequence version 1. DT 09-JUL-2014, entry version 25. DE RecName: Full=Polymerase acidic protein; DE AltName: Full=RNA-directed RNA polymerase subunit P2; GN Name=PA; OS Influenza A virus (strain A/Brazil/11/1978 H1N1). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=393560; OH NCBI_TaxID=8782; Aves. OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RA Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., RA Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., RA Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y., RA Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.; RT "The NIAID influenza genome sequencing project."; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Implicated in endonuclease cleavage of capped RNA CC primers. Displays an elongation factor activity in viral RNA CC synthesis. Dispensable for viral transcription, but not CC replication (By similarity). CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: CC PB1, PB2 and PA (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Ribosomal frameshifting; Named isoforms=2; CC Name=PA; CC IsoId=A4GBY4-1; Sequence=Displayed; CC Name=PA-X; CC IsoId=P0CK67-1; Sequence=External; CC -!- PTM: Phosphorylated on serines and threonines by host kinases, CC including human casein kinase II (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses PA family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY020298; ABO38072.1; -; Viral_cRNA. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR InterPro; IPR001009; RNA-dir_pol_influenzavirus. DR Pfam; PF00603; Flu_PA; 1. PE 3: Inferred from homology; KW Complete proteome; Eukaryotic host gene expression shutoff by virus; KW Eukaryotic host transcription shutoff by virus; KW Host gene expression shutoff by virus; Host-virus interaction; KW Inhibition of host RNA polymerase II by virus; Phosphoprotein; KW Ribosomal frameshifting. FT CHAIN 1 716 Polymerase acidic protein. FT /FTId=PRO_0000373005. SQ SEQUENCE 716 AA; 82761 MW; F7EC6B241DB645E7 CRC64; MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGES IIVELDDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET IEERFEITGT MRRLADQSLP PNFSCLENFR AYVDGFEPNG YIEGKLSQMS KEVNARIEPF LKTTPRPIRL PDGPPCSQRS KFLLMDALKL SIEDPSHEGE GIPLYDAIKC MRTFFGWKEP YVVKPHEKGI NPNYLLSWKQ VLAELQDIEN EGKIPRTKNM KKTSQLKWAL GENMAPEKVD FDDCKDISDL KQYDSDEPKL RSLSSWIQNE FNKACELTDS IWIELDEIGE DVAPIEHIAS MRRNYFTAEV SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY CVLEIGDMLL RSAIGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY ASPQLEGFSA ESRKLLLVVQ ALRDNLEPGT FDLGGLYEAI EECLINDPWV LLNASWFNSF LTHALR //