ID A4FV12_BOVIN Unreviewed; 640 AA. AC A4FV12; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 16-MAR-2016, entry version 77. DE SubName: Full=UBA2 protein {ECO:0000313|EMBL:AAI23591.1}; DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000003333}; GN Name=UBA2 {ECO:0000313|EMBL:AAI23591.1, GN ECO:0000313|Ensembl:ENSBTAP00000003333}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|EMBL:AAI23591.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hereford {ECO:0000313|EMBL:AAI23591.1}; RC TISSUE=Fetal lung {ECO:0000313|EMBL:AAI23591.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003333, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003333, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. CC {ECO:0000256|RuleBase:RU000519}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DAAA02046904; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC123590; AAI23591.1; -; mRNA. DR RefSeq; NP_001076850.1; NM_001083381.1. DR UniGene; Bt.13185; -. DR SMR; A4FV12; 4-550. DR STRING; 9913.ENSBTAP00000003333; -. DR Ensembl; ENSBTAT00000003333; ENSBTAP00000003333; ENSBTAG00000002573. DR GeneID; 507005; -. DR KEGG; bta:507005; -. DR CTD; 10054; -. DR eggNOG; KOG2013; Eukaryota. DR eggNOG; COG0476; LUCA. DR GeneTree; ENSGT00550000074924; -. DR HOGENOM; HOG000216514; -. DR HOVERGEN; HBG060266; -. DR KO; K10685; -. DR OMA; TAYHDSV; -. DR OrthoDB; EOG7S7SDB; -. DR TreeFam; TF300765; -. DR Reactome; R-BTA-3065676; SUMO is conjugated to E1 (UBA2:SAE1). DR Reactome; R-BTA-3065678; SUMO is transferred from E1 to E2 (UBE2I, UBC9). DR NextBio; 20867853; -. DR Proteomes; UP000009136; Chromosome 18. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0031510; C:SUMO activating enzyme complex; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0019948; F:SUMO activating enzyme activity; IBA:GO_Central. DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central. DR Gene3D; 1.10.3240.10; -; 1. DR Gene3D; 3.40.50.720; -; 2. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR030661; SAE2/Uba2. DR InterPro; IPR000594; ThiF_NAD_FAD-bd. DR InterPro; IPR028077; UAE_UbL_dom. DR InterPro; IPR032426; UBA2_C. DR InterPro; IPR019572; UBA_E1_Cys. DR InterPro; IPR018074; UBQ-activ_enz_E1_CS. DR InterPro; IPR033127; UBQ-activ_enz_E1_Cys_AS. DR Pfam; PF00899; ThiF; 1. DR Pfam; PF14732; UAE_UbL; 1. DR Pfam; PF16195; UBA2_C; 1. DR PIRSF; PIRSF039133; SUMO_E1B; 1. DR SUPFAM; SSF69572; SSF69572; 2. DR PROSITE; PS00536; UBIQUITIN_ACTIVAT_1; 1. DR PROSITE; PS00865; UBIQUITIN_ACTIVAT_2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|RuleBase:RU000519}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Ligase {ECO:0000256|RuleBase:RU000519}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU000519}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A4FV12}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}; KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU000519}. FT DOMAIN 10 433 ThiF. {ECO:0000259|Pfam:PF00899}. FT DOMAIN 452 537 UAE_UbL. {ECO:0000259|Pfam:PF14732}. FT DOMAIN 549 632 UBA2_C. {ECO:0000259|Pfam:PF16195}. SQ SEQUENCE 640 AA; 71031 MW; 4B1946642E4AE5DA CRC64; MALSRGLPRE LAEAVAGGRV LVVGAGGIGC ELLKNLVLTG FSHIDLIDLD TIDVSNLNRQ FLFQKKHVGR SKAQVAKESV LQFYPKANIV AYHDSIMNPD YNVEFFRQFI LVMNALDNRA ARNHVNRMCL AADVPLIESG TAGYLGQVTT IKKGVTECYE CHPKPTQRTF PGCTIRNTPS EPIHCIVWAK YLFNQLFGEE DADQEVSPDR ADPEASWEPM EAEARARASN EDGDIKRVST KEWAKSTGYD PVKLFTKLFK DDIRYLLTMD KLWRKRKPPV PLDWAEVQSQ GEETSASDQQ NEPQLGLKDQ QVLDVKSYAC LFSKSIETLR VHLAEKGDGA ELIWDKDDPS AMDFVTSAAN LRMHIFSMNM KSRFDIKSMA GNIIPAIATT NAVIAGLIVL EGLKILSGKI DQCRTIFLNK QPNPRKKLLV PCALDAPNPN CYVCASKPEV TVRLNVHKVT VLTLQDKIVK EKFAMVAPDV QIEDGKGTIL ISSEEGETEA NNHKKLSEFG IRNGSRLQAD DFLQDYTLLI NILHSEDLGK DVEFEVVGDA PEKVGPKQAE DAAKSITNGS DDGAQPSTST AQEQDDVLIV DSDEEGPSNN ADISEEERSR KRKLDEKESV SAKRSRIEQA EELDEVIALD //