ID A4FUP0_DANRE Unreviewed; 288 AA. AC A4FUP0; A0A8M1NC56; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 13-SEP-2023, entry version 105. DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155}; DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155}; GN OrderedLocusNames=sult2st3 {ECO:0000313|EMBL:AAI15351.1, GN ECO:0000313|RefSeq:NP_001071636.2, GN ECO:0000313|ZFIN:ZDB-GENE-061117-4}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI15351.1}; RN [1] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=17045951; DOI=10.1016/j.abb.2006.09.004; RA Yasuda S., Liu M.Y., Yang Y.S., Snow R., Takahashi S., Liu M.C.; RT "Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2 RT ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization, RT and developmental expression."; RL Arch. Biochem. Biophys. 455:1-9(2006). RN [2] {ECO:0000313|EMBL:AAI15351.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAI15351.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=20446911; RA Kurogi K., Dillon J., Nasser A., Liu M.Y., Williams F.E., Sakakibara Y., RA Suiko M., Liu M.C.; RT "Sulfation of drug compounds by the zebrafish cytosolic sulfotransferases RT (SULTs)."; RL Drug Metab Lett 4:62-68(2010). RN [4] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=21445457; RA Li Z.H., Alex D., Siu S.O., Chu I.K., Renn J., Winkler C., Lou S., RA Tsui S.K., Zhao H.Y., Yan W.R., Mahady G.B., Li G.H., Kwan Y.W., Wang Y.T., RA Lee S.M.; RT "Combined in vivo imaging and omics approaches reveal metabolism of RT icaritin and its glycosides in zebrafish larvae."; RL Mol. Biosyst. 7:2128-2138(2011). RN [5] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=22360938; RA Mohammed Y.I., Kurogi K., Shaban A.A., Xu Z., Liu M.Y., Williams F.E., RA Sakakibara Y., Suiko M., Bhuiyan S., Liu M.C.; RT "Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and RT SULT3 ST5."; RL Aquat. Toxicol. 112-113:11-18(2012). RN [6] {ECO:0000313|Ensembl:ENSDARP00000036121} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036121}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [7] {ECO:0000313|Ensembl:ENSDARP00000036121, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036121}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [8] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26308493; RA Fetter E., Smetanova S., Baldauf L., Lidzba A., Altenburger R., RA Schuttler A., Scholz S.; RT "Identification and Characterization of Androgen-Responsive Genes in RT Zebrafish Embryos."; RL Environ. Sci. Technol. 49:11789-11798(2015). RN [9] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=29078070; RA Fraser T.W.K., Khezri A., Lewandowska-Sabat A.M., Henry T., Ropstad E.; RT "Endocrine disruptors affect larval zebrafish behavior: Testing potential RT mechanisms and comparisons of behavioral sensitivity to alternative RT biomarkers."; RL Aquat. Toxicol. 193:128-135(2017). RN [10] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=28807679; RA Kurogi K., Yoshihama M., Horton A., Schiefer I.T., Krasowski M.D., RA Hagey L.R., Williams F.E., Sakakibara Y., Kenmochi N., Suiko M., Liu M.C.; RT "Identification and characterization of 5alpha-cyprinol-sulfating cytosolic RT sulfotransferases (Sults) in the zebrafish (Danio rerio)."; RL J. Steroid Biochem. Mol. Biol. 174:120-127(2017). RN [11] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=28242321; RA Chatzopoulou A., Schoonheim P.J., Torraca V., Meijer A.H., Spaink H.P., RA Schaaf M.J.; RT "Functional analysis reveals no transcriptional role for the glucocorticoid RT receptor beta-isoform in zebrafish."; RL Mol. Cell. Endocrinol. 447:61-70(2017). RN [12] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=29960009; RA Fent K., Siegenthaler P.F., Schmid A.A.; RT "Transcriptional effects of androstenedione and 17alpha-hydroxyprogesterone RT in zebrafish embryos."; RL Aquat. Toxicol. 202:1-5(2018). RN [13] {ECO:0000313|RefSeq:NP_001071636.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=30965663; RA Jarque S., Ibarra J., Rubio-Brotons M., Garcia-Fernandez J., Terriente J.; RT "Multiplex Analysis Platform for Endocrine Disruption Prediction Using RT Zebrafish."; RL Int. J. Mol. Sci. 20:E1739-E1739(2019). RN [14] {ECO:0000313|RefSeq:NP_001071636.2, ECO:0000313|RefSeq:XP_017206856.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017206856.1}; RG RefSeq; RL Submitted (MAR-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. CC {ECO:0000256|RuleBase:RU361155}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX511252; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC115350; AAI15351.1; -; mRNA. DR RefSeq; NP_001071636.2; NM_001078168.2. DR RefSeq; XP_017206856.1; XM_017351367.1. DR STRING; 7955.ENSDARP00000036121; -. DR Ensembl; ENSDART00000037797.7; ENSDARP00000036121.5; ENSDARG00000028367.7. DR GeneID; 777792; -. DR KEGG; dre:777792; -. DR CTD; 777792; -. DR ZFIN; ZDB-GENE-061117-4; sult2st3. DR eggNOG; KOG1584; Eukaryota. DR OMA; QNFPKER; -. DR OrthoDB; 3083090at2759; -. DR TreeFam; TF321745; -. DR BRENDA; 2.8.2.32; 928. DR Reactome; R-DRE-156584; Cytosolic sulfonation of small molecules. DR Reactome; R-DRE-9753281; Paracetamol ADME. DR Proteomes; UP000000437; Chromosome 16. DR Bgee; ENSDARG00000028367; Expressed in zone of skin and 19 other tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0008146; F:sulfotransferase activity; IDA:ZFIN. DR GO; GO:0009725; P:response to hormone; IDA:ZFIN. DR GO; GO:0033574; P:response to testosterone; IDA:ZFIN. DR GO; GO:0051923; P:sulfation; IDA:ZFIN. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000863; Sulfotransferase_dom. DR PANTHER; PTHR11783:SF9; SULFOTRANSFERASE 2B1; 1. DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1. DR Pfam; PF00685; Sulfotransfer_1; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|PeptideAtlas:A4FUP0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:AAI15351.1}. FT DOMAIN 35..279 FT /note="Sulfotransferase" FT /evidence="ECO:0000259|Pfam:PF00685" SQ SEQUENCE 288 AA; 33460 MW; AE6E734E7DF5BAFB CRC64; MEVSEFNLLY KGFLLPKLAH TEESLQYLEN FKVKDDDVFA VTYPKSGTTW MQNILPPLLN GGDLTPVQTV PNWDRAPWLE EIRAAVVLEE RPSPRAIVSH MPYRLMPSSF YKSKAKVIYV ARNPKDVIVS SYHFHKMASF LEDPGTFDDF VNKFLSGEIV FGKWSDHIKS WRNPELKDRI LYVTYEEMLQ DLRGVLCRML KFLGRELSTE ALDRVVSNST FKNMKTNKMS NYTMVPQEIM DNNKSAFLRK GVAGDWKNFF SPELDAKFTA VIREEMKGTN IKFPWDEE //