ID   A4FUP0_DANRE            Unreviewed;       288 AA.
AC   A4FUP0; A0A8M1NC56;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   14-DEC-2022, entry version 101.
DE   RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN   Name=sult2st3 {ECO:0000313|RefSeq:NP_001071636.2,
GN   ECO:0000313|RefSeq:XP_017206856.1};
GN   OrderedLocusNames=sult2st3 {ECO:0000313|EMBL:AAI15351.1,
GN   ECO:0000313|Ensembl:ENSDARP00000036121,
GN   ECO:0000313|ZFIN:ZDB-GENE-061117-4};
GN   ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-061117-4};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI15351.1};
RN   [1] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17045951; DOI=10.1016/j.abb.2006.09.004;
RA   Yasuda S., Liu M.Y., Yang Y.S., Snow R., Takahashi S., Liu M.C.;
RT   "Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2
RT   ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization,
RT   and developmental expression.";
RL   Arch. Biochem. Biophys. 455:1-9(2006).
RN   [2] {ECO:0000313|EMBL:AAI15351.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole {ECO:0000313|EMBL:AAI15351.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20446911;
RA   Kurogi K., Dillon J., Nasser A., Liu M.Y., Williams F.E., Sakakibara Y.,
RA   Suiko M., Liu M.C.;
RT   "Sulfation of drug compounds by the zebrafish cytosolic sulfotransferases
RT   (SULTs).";
RL   Drug Metab Lett 4:62-68(2010).
RN   [4] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21445457;
RA   Li Z.H., Alex D., Siu S.O., Chu I.K., Renn J., Winkler C., Lou S.,
RA   Tsui S.K., Zhao H.Y., Yan W.R., Mahady G.B., Li G.H., Kwan Y.W., Wang Y.T.,
RA   Lee S.M.;
RT   "Combined in vivo imaging and omics approaches reveal metabolism of
RT   icaritin and its glycosides in zebrafish larvae.";
RL   Mol. Biosyst. 7:2128-2138(2011).
RN   [5] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22360938;
RA   Mohammed Y.I., Kurogi K., Shaban A.A., Xu Z., Liu M.Y., Williams F.E.,
RA   Sakakibara Y., Suiko M., Bhuiyan S., Liu M.C.;
RT   "Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and
RT   SULT3 ST5.";
RL   Aquat. Toxicol. 112-113:11-18(2012).
RN   [6] {ECO:0000313|Ensembl:ENSDARP00000036121}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036121};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [7] {ECO:0000313|Ensembl:ENSDARP00000036121}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000036121};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [8] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26308493;
RA   Fetter E., Smetanova S., Baldauf L., Lidzba A., Altenburger R.,
RA   Schuttler A., Scholz S.;
RT   "Identification and Characterization of Androgen-Responsive Genes in
RT   Zebrafish Embryos.";
RL   Environ. Sci. Technol. 49:11789-11798(2015).
RN   [9] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29078070;
RA   Fraser T.W.K., Khezri A., Lewandowska-Sabat A.M., Henry T., Ropstad E.;
RT   "Endocrine disruptors affect larval zebrafish behavior: Testing potential
RT   mechanisms and comparisons of behavioral sensitivity to alternative
RT   biomarkers.";
RL   Aquat. Toxicol. 193:128-135(2017).
RN   [10] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28807679;
RA   Kurogi K., Yoshihama M., Horton A., Schiefer I.T., Krasowski M.D.,
RA   Hagey L.R., Williams F.E., Sakakibara Y., Kenmochi N., Suiko M., Liu M.C.;
RT   "Identification and characterization of 5alpha-cyprinol-sulfating cytosolic
RT   sulfotransferases (Sults) in the zebrafish (Danio rerio).";
RL   J. Steroid Biochem. Mol. Biol. 174:120-127(2017).
RN   [11] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28242321;
RA   Chatzopoulou A., Schoonheim P.J., Torraca V., Meijer A.H., Spaink H.P.,
RA   Schaaf M.J.;
RT   "Functional analysis reveals no transcriptional role for the glucocorticoid
RT   receptor beta-isoform in zebrafish.";
RL   Mol. Cell. Endocrinol. 447:61-70(2017).
RN   [12] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29960009;
RA   Fent K., Siegenthaler P.F., Schmid A.A.;
RT   "Transcriptional effects of androstenedione and 17alpha-hydroxyprogesterone
RT   in zebrafish embryos.";
RL   Aquat. Toxicol. 202:1-5(2018).
RN   [13] {ECO:0000313|RefSeq:NP_001071636.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30965663;
RA   Jarque S., Ibarra J., Rubio-Brotons M., Garcia-Fernandez J., Terriente J.;
RT   "Multiplex Analysis Platform for Endocrine Disruption Prediction Using
RT   Zebrafish.";
RL   Int. J. Mol. Sci. 20:E1739-E1739(2019).
RN   [14] {ECO:0000313|RefSeq:NP_001071636.2, ECO:0000313|RefSeq:XP_017206856.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017206856.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC       {ECO:0000256|RuleBase:RU361155}.
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DR   EMBL; BX511252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC115350; AAI15351.1; -; mRNA.
DR   RefSeq; NP_001071636.2; NM_001078168.2.
DR   RefSeq; XP_017206856.1; XM_017351367.1.
DR   SMR; A4FUP0; -.
DR   STRING; 7955.ENSDARP00000036121; -.
DR   PeptideAtlas; A4FUP0; -.
DR   Ensembl; ENSDART00000037797.7; ENSDARP00000036121.5; ENSDARG00000028367.7.
DR   GeneID; 777792; -.
DR   KEGG; dre:777792; -.
DR   CTD; 777792; -.
DR   ZFIN; ZDB-GENE-061117-4; SO:0001217.
DR   ZFIN; ZDB-GENE-061117-4; sult2st3.
DR   eggNOG; KOG1584; Eukaryota.
DR   GeneTree; ENSGT00940000166159; -.
DR   OMA; DTPYHRH; -.
DR   OrthoDB; 780670at2759; -.
DR   TreeFam; TF321745; -.
DR   BRENDA; 2.8.2.32; 928.
DR   Reactome; R-DRE-156584; Cytosolic sulfonation of small molecules.
DR   Reactome; R-DRE-9753281; Paracetamol ADME.
DR   Proteomes; UP000000437; Chromosome 16.
DR   Bgee; ENSDARG00000028367; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008146; F:sulfotransferase activity; IDA:ZFIN.
DR   GO; GO:0009725; P:response to hormone; IDA:ZFIN.
DR   GO; GO:0033574; P:response to testosterone; IDA:ZFIN.
DR   GO; GO:0051923; P:sulfation; IDA:ZFIN.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:AAI15351.1}.
FT   DOMAIN          35..279
FT                   /note="Sulfotransfer_1"
FT                   /evidence="ECO:0000259|Pfam:PF00685"
SQ   SEQUENCE   288 AA;  33460 MW;  AE6E734E7DF5BAFB CRC64;
     MEVSEFNLLY KGFLLPKLAH TEESLQYLEN FKVKDDDVFA VTYPKSGTTW MQNILPPLLN
     GGDLTPVQTV PNWDRAPWLE EIRAAVVLEE RPSPRAIVSH MPYRLMPSSF YKSKAKVIYV
     ARNPKDVIVS SYHFHKMASF LEDPGTFDDF VNKFLSGEIV FGKWSDHIKS WRNPELKDRI
     LYVTYEEMLQ DLRGVLCRML KFLGRELSTE ALDRVVSNST FKNMKTNKMS NYTMVPQEIM
     DNNKSAFLRK GVAGDWKNFF SPELDAKFTA VIREEMKGTN IKFPWDEE
//