ID A4FUG5_BOVIN Unreviewed; 519 AA. AC A4FUG5; A0A3S5ZP74; F1MU16; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 02-OCT-2024, entry version 117. DE SubName: Full=BIN2 protein {ECO:0000313|EMBL:AAI14870.1}; DE SubName: Full=Bridging integrator 2 {ECO:0000313|Ensembl:ENSBTAP00000044263.5}; GN Name=BIN2 {ECO:0000313|EMBL:AAI14870.1, GN ECO:0000313|Ensembl:ENSBTAP00000044263.5, GN ECO:0000313|VGNC:VGNC:26498}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI14870.1}; RN [1] {ECO:0000313|EMBL:AAI14870.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hereford {ECO:0000313|EMBL:AAI14870.1}; RC TISSUE=Thymus {ECO:0000313|EMBL:AAI14870.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A., RA Holt R., Jones S.J., Marra M.A.; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000044263.5, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044263.5, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSBTAP00000044263.5} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000044263.5}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC114869; AAI14870.1; -; mRNA. DR RefSeq; NP_001076904.1; NM_001083435.2. DR STRING; 9913.ENSBTAP00000068624; -. DR PaxDb; 9913-ENSBTAP00000044263; -. DR Ensembl; ENSBTAT00000047025.5; ENSBTAP00000044263.5; ENSBTAG00000008897.7. DR GeneID; 515025; -. DR KEGG; bta:515025; -. DR CTD; 51411; -. DR VEuPathDB; HostDB:ENSBTAG00000008897; -. DR VGNC; VGNC:26498; BIN2. DR eggNOG; KOG3771; Eukaryota. DR GeneTree; ENSGT00950000182882; -. DR HOGENOM; CLU_017859_7_0_1; -. DR OMA; ENHRARG; -. DR OrthoDB; 4243832at2759; -. DR TreeFam; TF313542; -. DR Reactome; R-BTA-6798695; Neutrophil degranulation. DR Proteomes; UP000009136; Chromosome 5. DR Bgee; ENSBTAG00000008897; Expressed in blood and 106 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0002102; C:podosome; IBA:GO_Central. DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central. DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl. DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central. DR GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central. DR GO; GO:0071800; P:podosome assembly; IBA:GO_Central. DR CDD; cd07612; BAR_Bin2; 1. DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR003005; Amphiphysin. DR InterPro; IPR046984; BAR_Bin2. DR InterPro; IPR004148; BAR_dom. DR InterPro; IPR048886; Bin2_C. DR PANTHER; PTHR46514; AMPHIPHYSIN; 1. DR PANTHER; PTHR46514:SF1; BRIDGING INTEGRATOR 2; 1. DR Pfam; PF03114; BAR; 1. DR Pfam; PF21532; Bin2_C; 1. DR PRINTS; PR01251; AMPHIPHYSIN. DR SMART; SM00721; BAR; 1. DR SUPFAM; SSF103657; BAR/IMD domain-like; 1. DR PROSITE; PS51021; BAR; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 28..244 FT /note="BAR" FT /evidence="ECO:0000259|PROSITE:PS51021" FT REGION 267..519 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 156..190 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 267..290 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 308..326 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 373..394 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 426..449 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 456..470 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 471..495 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 519 AA; 57458 MW; F1731BAAE2759AA7 CRC64; MAEGRAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKTVETKD ERFEQSASNF HQQQAEGHKL YKDLKNFLSA VKVMHESSKR VSETLQEIYS SKWDGHEELK AIVANNDLLW EDYEEKLADQ VLRTMENYVA QFSEIKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA QLVFEDLNQE LLEELPVLYN SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK QHSDKVFVVK GLSSSNRRSL VISPPVRTSM VSSPITSPTS PSALSLKSEK DSSSASEEEL ASDSAQGEDN SEIKEEPLKD KETEEEAETS SSEEEEPLPA CNGPIQSQPS PLTEDRESQE EVFPCSPAPS PARALTPSEQ ASSSSVVVLR TRTSSEGSEE LKKKVSVQRA SAPPSRPPPP RATPSPRGSL GNTPSSPPAS PTSPRASSEA SPDPQPPEKP VREKENTDNL NPEELCTSPT LMNSQNQSLQ LHGSAVPEES NVIAPEPEEE VSTIQSAQL //