ID   A4FUG5_BOVIN            Unreviewed;       519 AA.
AC   A4FUG5; F1MU16;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   12-OCT-2022, entry version 106.
DE   SubName: Full=BIN2 protein {ECO:0000313|EMBL:AAI14870.1};
DE   SubName: Full=Bridging integrator 2 {ECO:0000313|Ensembl:ENSBTAP00000068624};
GN   Name=BIN2 {ECO:0000313|EMBL:AAI14870.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000068624, ECO:0000313|VGNC:VGNC:26498};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI14870.1};
RN   [1] {ECO:0000313|EMBL:AAI14870.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI14870.1};
RC   TISSUE=Thymus {ECO:0000313|EMBL:AAI14870.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000068624, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068624,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000068624}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068624};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
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DR   EMBL; BC114869; AAI14870.1; -; mRNA.
DR   RefSeq; NP_001076904.1; NM_001083435.2.
DR   SMR; A4FUG5; -.
DR   STRING; 9913.ENSBTAP00000044263; -.
DR   PRIDE; A4FUG5; -.
DR   Ensembl; ENSBTAT00000073034.1; ENSBTAP00000068624.1; ENSBTAG00000008897.6.
DR   GeneID; 515025; -.
DR   KEGG; bta:515025; -.
DR   CTD; 51411; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008897; -.
DR   VGNC; VGNC:26498; BIN2.
DR   eggNOG; KOG3771; Eukaryota.
DR   GeneTree; ENSGT00950000182882; -.
DR   HOGENOM; CLU_017859_7_0_1; -.
DR   OMA; STMQNTH; -.
DR   OrthoDB; 1366218at2759; -.
DR   TreeFam; TF313542; -.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000008897; Expressed in blood and 106 other tissues.
DR   ExpressionAtlas; A4FUG5; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0002102; C:podosome; IBA:GO_Central.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR   GO; GO:0071800; P:podosome assembly; IBA:GO_Central.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR003005; Amphiphysin.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR028827; BIN2.
DR   PANTHER; PTHR46514:SF1; PTHR46514:SF1; 1.
DR   Pfam; PF03114; BAR; 1.
DR   PRINTS; PR01251; AMPHIPHYSIN.
DR   SMART; SM00721; BAR; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS51021; BAR; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          28..244
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   REGION          267..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..190
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        267..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  57458 MW;  F1731BAAE2759AA7 CRC64;
     MAEGRAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKTVETKD ERFEQSASNF HQQQAEGHKL
     YKDLKNFLSA VKVMHESSKR VSETLQEIYS SKWDGHEELK AIVANNDLLW EDYEEKLADQ
     VLRTMENYVA QFSEIKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA
     QLVFEDLNQE LLEELPVLYN SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK
     QHSDKVFVVK GLSSSNRRSL VISPPVRTSM VSSPITSPTS PSALSLKSEK DSSSASEEEL
     ASDSAQGEDN SEIKEEPLKD KETEEEAETS SSEEEEPLPA CNGPIQSQPS PLTEDRESQE
     EVFPCSPAPS PARALTPSEQ ASSSSVVVLR TRTSSEGSEE LKKKVSVQRA SAPPSRPPPP
     RATPSPRGSL GNTPSSPPAS PTSPRASSEA SPDPQPPEKP VREKENTDNL NPEELCTSPT
     LMNSQNQSLQ LHGSAVPEES NVIAPEPEEE VSTIQSAQL
//