ID   A4FUD0_BOVIN            Unreviewed;       935 AA.
AC   A4FUD0;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   20-JAN-2016, entry version 82.
DE   SubName: Full=MTHFD1 protein {ECO:0000313|EMBL:AAI14712.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSBTAP00000012704};
GN   Name=MTHFD1 {ECO:0000313|EMBL:AAI14712.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000012704};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000313|EMBL:AAI14712.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI14712.1};
RC   TISSUE=Uterus {ECO:0000313|EMBL:AAI14712.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
RA   Siddiqui A., Holt R., Jones S.J., Marra M.A.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000012704, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012704,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
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DR   EMBL; DAAA02029399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC114711; AAI14712.1; -; mRNA.
DR   RefSeq; NP_001076946.1; NM_001083477.1.
DR   UniGene; Bt.3017; -.
DR   STRING; 9913.ENSBTAP00000012704; -.
DR   Ensembl; ENSBTAT00000012704; ENSBTAP00000012704; ENSBTAG00000009641.
DR   GeneID; 534382; -.
DR   KEGG; bta:534382; -.
DR   CTD; 4522; -.
DR   eggNOG; COG0190; LUCA.
DR   eggNOG; COG2759; LUCA.
DR   eggNOG; KOG4230; Eukaryota.
DR   GeneTree; ENSGT00800000124065; -.
DR   HOGENOM; HOG000040280; -.
DR   HOVERGEN; HBG004916; -.
DR   KO; K00288; -.
DR   OMA; FAPLMFK; -.
DR   OrthoDB; EOG76T9QN; -.
DR   TreeFam; TF300623; -.
DR   Reactome; R-BTA-196757; Metabolism of folate and pterines.
DR   NextBio; 20876382; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IBA:GO_Central.
DR   GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IBA:GO_Central.
DR   GO; GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:Ensembl.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR   GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0009070; P:serine family amino acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0061053; P:somite development; IEA:Ensembl.
DR   GO; GO:0019346; P:transsulfuration; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; -; 2.
DR   Gene3D; 3.40.50.720; -; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Pfam; PF01268; FTHFS; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
DR   PROSITE; PS00766; THF_DHG_CYH_1; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A4FUD0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN        6    125       THF_DHG_CYH. {ECO:0000259|Pfam:PF00763}.
FT   DOMAIN      129    293       THF_DHG_CYH_C. {ECO:0000259|Pfam:
FT                                PF02882}.
SQ   SEQUENCE   935 AA;  101177 MW;  BF41B702ED19850A CRC64;
     MAPAEILNGK VVSAQIKERL KNQVIQMKEE VPGFIPGLAI LQVGNRDDSN LYINMKLKAA
     EEIGIKATHI KLPRTATESE VLKCITSLNE DLTVHGFIVQ LPLDSENPIN TETLVNAIAP
     EKDVDGLNSI SAGKLARGDL SNCFIPCTPK GCLELIKETG VQIAGRHAVV VGRSKIVGAP
     MHDLLLWNHA TVTTCHSKTA NLKEEISKGD ILVVAAGQPE MVKGEWIKPG AIVIDCGINY
     VTDDTKPNGK KIVGDVAYTE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLENFKP
     GKWIIQYNKL NLKTPVPSDI DISRSYKPKP IGNLAREVGL RTEEVELYGE TKAKVLLSAL
     ERLKHQPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGTH LHQNVFACVR QPSQGPTFGI
     KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARMFHEETQ TDKALFNRLV
     PSVNGVRKFS DIQIRRLRRL GIEKTDPATL TDEEINRFAR LDIDPETITW QRVLDTNDRF
     LRKITIGQAP TEKGHSRTAQ FDISVASEIM AVLALTSSLE DMRERLGKMV VASSKKGEPI
     STEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG
     PEGFVVTEAG FGADIGMEKF FNIKCRYSGL RPHVVVLVAT VRALKMHGGG PTVTAGLPLP
     KAYIEEDLEL VGKGFSNLKK QIENARMFGV PVVVAVNAFK TDTEAELDLV SRLAKEHGAF
     DAVKCTHWAE GGKGALALAE AVQRAAAAPS SFQLLYDLKL PVEDKIRIIA QKIYGADNIE
     LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPELKGV PTGFVLPIRD IRASVGAGFL
     YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF
//