ID A4FUD0_BOVIN Unreviewed; 935 AA. AC A4FUD0; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 10-APR-2019, entry version 108. DE SubName: Full=MTHFD1 protein {ECO:0000313|EMBL:AAI14712.1}; GN Name=MTHFD1 {ECO:0000313|EMBL:AAI14712.1, GN ECO:0000313|Ensembl:ENSBTAP00000012704, ECO:0000313|VGNC:VGNC:31730}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI14712.1}; RN [1] {ECO:0000313|EMBL:AAI14712.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI14712.1}; RC TISSUE=Uterus {ECO:0000313|EMBL:AAI14712.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., RA Siddiqui A., Holt R., Jones S.J., Marra M.A.; RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000012704, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012704, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [3] {ECO:0000313|Ensembl:ENSBTAP00000012704} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012704}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC114711; AAI14712.1; -; mRNA. DR RefSeq; NP_001076946.1; NM_001083477.1. DR UniGene; Bt.3017; -. DR STRING; 9913.ENSBTAP00000012704; -. DR Ensembl; ENSBTAT00000012704; ENSBTAP00000012704; ENSBTAG00000009641. DR GeneID; 534382; -. DR KEGG; bta:534382; -. DR CTD; 4522; -. DR VGNC; VGNC:31730; MTHFD1. DR eggNOG; KOG4230; Eukaryota. DR eggNOG; COG0190; LUCA. DR eggNOG; COG2759; LUCA. DR GeneTree; ENSGT00940000154746; -. DR HOGENOM; HOG000040280; -. DR HOVERGEN; HBG004916; -. DR KO; K00288; -. DR OMA; GFHAYNI; -. DR OrthoDB; 690393at2759; -. DR TreeFam; TF300623; -. DR Reactome; R-BTA-196757; Metabolism of folate and pterines. DR Proteomes; UP000009136; Chromosome 10. DR Bgee; ENSBTAG00000009641; Expressed in 10 organ(s), highest expression level in liver. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IBA:GO_Central. DR GO; GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IBA:GO_Central. DR GO; GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:Ensembl. DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IBA:GO_Central. DR GO; GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; IEA:Ensembl. DR GO; GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IBA:GO_Central. DR GO; GO:0007507; P:heart development; IEA:Ensembl. DR GO; GO:0009086; P:methionine biosynthetic process; IEA:Ensembl. DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl. DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl. DR GO; GO:0009113; P:purine nucleobase biosynthetic process; IBA:GO_Central. DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:Ensembl. DR GO; GO:0009070; P:serine family amino acid biosynthetic process; IEA:Ensembl. DR GO; GO:0061053; P:somite development; IEA:Ensembl. DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:Ensembl. DR GO; GO:0019346; P:transsulfuration; IEA:Ensembl. DR CDD; cd00477; FTHFS; 1. DR CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1. DR HAMAP; MF_01543; FTHFS; 1. DR HAMAP; MF_01576; THF_DHG_CYH; 1. DR InterPro; IPR000559; Formate_THF_ligase. DR InterPro; IPR020628; Formate_THF_ligase_CS. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000672; THF_DH/CycHdrlase. DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom. DR InterPro; IPR020867; THF_DH/CycHdrlase_CS. DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. DR Pfam; PF01268; FTHFS; 1. DR Pfam; PF00763; THF_DHG_CYH; 1. DR Pfam; PF02882; THF_DHG_CYH_C; 1. DR PRINTS; PR00085; THFDHDRGNASE. DR SUPFAM; SSF51735; SSF51735; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00721; FTHFS_1; 1. DR PROSITE; PS00722; FTHFS_2; 1. DR PROSITE; PS00766; THF_DHG_CYH_1; 1. DR PROSITE; PS00767; THF_DHG_CYH_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A4FUD0}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 6 125 THF_DHG_CYH. {ECO:0000259|Pfam:PF00763}. FT DOMAIN 129 293 THF_DHG_CYH_C. {ECO:0000259|Pfam: FT PF02882}. SQ SEQUENCE 935 AA; 101177 MW; BF41B702ED19850A CRC64; MAPAEILNGK VVSAQIKERL KNQVIQMKEE VPGFIPGLAI LQVGNRDDSN LYINMKLKAA EEIGIKATHI KLPRTATESE VLKCITSLNE DLTVHGFIVQ LPLDSENPIN TETLVNAIAP EKDVDGLNSI SAGKLARGDL SNCFIPCTPK GCLELIKETG VQIAGRHAVV VGRSKIVGAP MHDLLLWNHA TVTTCHSKTA NLKEEISKGD ILVVAAGQPE MVKGEWIKPG AIVIDCGINY VTDDTKPNGK KIVGDVAYTE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLENFKP GKWIIQYNKL NLKTPVPSDI DISRSYKPKP IGNLAREVGL RTEEVELYGE TKAKVLLSAL ERLKHQPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGTH LHQNVFACVR QPSQGPTFGI KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARMFHEETQ TDKALFNRLV PSVNGVRKFS DIQIRRLRRL GIEKTDPATL TDEEINRFAR LDIDPETITW QRVLDTNDRF LRKITIGQAP TEKGHSRTAQ FDISVASEIM AVLALTSSLE DMRERLGKMV VASSKKGEPI STEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG PEGFVVTEAG FGADIGMEKF FNIKCRYSGL RPHVVVLVAT VRALKMHGGG PTVTAGLPLP KAYIEEDLEL VGKGFSNLKK QIENARMFGV PVVVAVNAFK TDTEAELDLV SRLAKEHGAF DAVKCTHWAE GGKGALALAE AVQRAAAAPS SFQLLYDLKL PVEDKIRIIA QKIYGADNIE LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPELKGV PTGFVLPIRD IRASVGAGFL YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF //