ID A4FUA6_HUMAN Unreviewed; 740 AA. AC A4FUA6; E9PEW6; DT 17-APR-2007, integrated into UniProtKB/TrEMBL. DT 17-APR-2007, sequence version 1. DT 10-MAY-2017, entry version 50. DE RecName: Full=Transmembrane channel-like protein {ECO:0000256|RuleBase:RU310713}; DE Flags: Fragment; GN Name=TMC1 {ECO:0000313|EMBL:AAI14381.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI14381.1}; RN [1] {ECO:0000313|EMBL:AAI14381.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU310713}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU310713}. CC -!- SIMILARITY: Belongs to the TMC family. CC {ECO:0000256|RuleBase:RU310713}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC114380; AAI14381.1; -; mRNA. DR UniGene; Hs.670211; -. DR PeptideAtlas; A4FUA6; -. DR PRIDE; A4FUA6; -. DR HOGENOM; HOG000231742; -. DR HOVERGEN; HBG036209; -. DR ChiTaRS; TMC1; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR InterPro; IPR012496; TMC. DR Pfam; PF07810; TMC; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|RuleBase:RU310713}; KW Transmembrane {ECO:0000256|RuleBase:RU310713}; KW Transmembrane helix {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 163 184 Helical. {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 238 260 Helical. {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 333 354 Helical. {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 409 429 Helical. {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 602 623 Helical. {ECO:0000256|RuleBase:RU310713}. FT TRANSMEM 663 683 Helical. {ECO:0000256|RuleBase:RU310713}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAI14381.1}. FT NON_TER 740 740 {ECO:0000313|EMBL:AAI14381.1}. SQ SEQUENCE 740 AA; 85476 MW; 5B27FE5F2DEEB9DC CRC64; VEWSGECLRS CRREVQIKVE EKEDETEESS SEEEEEVEDK LPRRESLRPK RKRTRDVINE DDPEPEPEDE ETRKAREKER RRRLKRGAEA KKFVSENEGA LGKGKGKRWF AFKMMMAKKW AKFLRDFENF KAACVPWENK IKAIESQFGS SVASYFLFLR WMYGVNMVLF ILTFSLIMLP EYLWGLPYGS LPRKTVPRAE EASAANFGVL YDFNGLAQYS VLFYGYYDNK RTIGWMNFRL PLSYFLVGIM CIGYSFLVVL KAMTKNIGDD GGGDDNTFNF SWKVFTSWDY LIGNPETADN KFNSITMNFK EAITEEKAAQ VEENVHLIRF LRFLANFFVF LTLGGSGYLI FWAVKRSQEF AQQDPDTLGW WEKNEMNMVM SLLGMFCPTL FDLFAELEDY HPLIALKWLL GRIFALLLGN LYVFILALMD EINNKIEEEK LVKANITLWE ANMIKAYNAS FSENSTGPPF FVHPADVPRG PCWETMVGQE FVRLTVSDVL TTYVTILIGD FLRACFVRFC NYCWCWDLEY GYPSYTEFDI SGNVLALIFN QGMIWMGSFF APSLPGINIL RLHTSMYFQC WAVMCCNVPE ARVFKASRSN NFYLGMLLLI LFLSTMPVLY MIVSLPPSFD CGPFSGKNRM FEVIGETLEH DFPSWMAKIL RQLSNPGLVI AVILVMVLAI YYLNATAKGQ KAANLDLKKK MKMLQLLVAS NKYPESPEKV HFALLFKSNA ICERPENKHC //