ID A4D2P4_HUMAN Unreviewed; 212 AA. AC A4D2P4; DT 03-APR-2007, integrated into UniProtKB/TrEMBL. DT 03-APR-2007, sequence version 1. DT 03-MAR-2009, entry version 15. DE RecName: Full=ER lumen protein retaining receptor; GN Name=KDELR2; ORFNames=hCG_15972, tcag7.840; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22616434; PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., RA Mural R.J., Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [2] RP NUCLEOTIDE SEQUENCE. RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., RA Kwasnicka D., Zheng X.H., Nusskern D., Zhang Q., Gu Z., Lu F., RA Zeesman S., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P., Lococo F., Belloni E., RA Shaffer L.G., Morton C.C., Pober B., Gusella J., Bruns G., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., RA Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., RA Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.Angel., RA Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., RA Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., RA Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., RA Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., RA Tsui L.-C.; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis; RA Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., RA Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., RA Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., RA Isogai T.; RT "NEDO functional analysis of protein and research application RT project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for the retention of luminal endoplasmic CC reticulum proteins. Determines the specificity of the luminal ER CC protein retention system. Also required for normal vesicular CC traffic through the Golgi (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By CC similarity). CC -!- SIMILARITY: Belongs to the ERD2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315702; BAG38064.1; -; mRNA. DR EMBL; CH236963; EAL23722.1; -; Genomic_DNA. DR EMBL; CH878731; EAW55030.1; -; Genomic_DNA. DR IPI; IPI00018248; -. DR RefSeq; NP_006845.1; -. DR UniGene; Hs.654552; -. DR PRIDE; A4D2P4; -. DR Ensembl; ENSG00000136240; Homo sapiens. DR GeneID; 11014; -. DR NextBio; 41841; -. DR Bgee; A4D2P4; -. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0046923; F:ER retention sequence binding; IEA:InterPro. DR GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW. DR GO; GO:0006621; P:protein retention in ER lumen; IEA:InterPro. DR InterPro; IPR000133; ER_ret_rcpt. DR PANTHER; PTHR10585; ER_ret_rcpt; 1. DR Pfam; PF00810; ER_lumen_recept; 1. DR PRINTS; PR00660; ERLUMENR. DR ProDom; PD005774; ERret_receptor; 1. DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1. DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1. PE 2: Evidence at transcript level; KW Endoplasmic reticulum; Protein transport; Receptor; Transmembrane; KW Transport. SQ SEQUENCE 212 AA; 24422 MW; 81BECB983E503142 CRC64; MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT KVLKGKKLSL PA //