ID A3R785_9TRYP Unreviewed; 512 AA. AC A3R785; DT 03-APR-2007, integrated into UniProtKB/TrEMBL. DT 03-APR-2007, sequence version 1. DT 27-MAR-2024, entry version 24. DE SubName: Full=Variant surface glycoprotein {ECO:0000313|EMBL:ABN70727.1}; GN Name=VSG {ECO:0000313|EMBL:ABN70727.1}; OS Trypanosoma brucei. OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Trypanosoma. OX NCBI_TaxID=5691 {ECO:0000313|EMBL:ABN70727.1}; RN [1] {ECO:0000313|EMBL:ABN70727.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TREU 927 {ECO:0000313|EMBL:ABN70727.1}; RX PubMed=17652423; DOI=10.1101/gr.6421207; RA Marcello L., Barry J.D.; RT "Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that RT mosaic gene expression is prominent in antigenic variation and is favored RT by archive substructure."; RL Genome Res. 17:1344-1352(2007). CC -!- FUNCTION: VSG forms a coat on the surface of the parasite. The CC trypanosome evades the immune response of the host by expressing a CC series of antigenically distinct VSGs from an estimated 1000 VSG genes. CC {ECO:0000256|ARBA:ARBA00002523}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor CC {ECO:0000256|ARBA:ARBA00004589}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF174490; ABN70727.1; -; mRNA. DR AlphaFoldDB; A3R785; -. DR VEuPathDB; TriTrypDB:Tb427_000435800; -. DR VEuPathDB; TriTrypDB:Tb927.11.20570; -. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR025932; Trypano_VSG_B_N_dom. DR InterPro; IPR019609; Variant_surf_glycoprt_trypan_C. DR Pfam; PF10659; Trypan_glycop_C; 1. DR Pfam; PF13206; VSG_B; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00022475}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..512 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002658004" FT DOMAIN 88..354 FT /note="Trypanosome variant surface glycoprotein B-type N- FT terminal" FT /evidence="ECO:0000259|Pfam:PF13206" FT DOMAIN 394..511 FT /note="Trypanosome variant surface glycoprotein C-terminal" FT /evidence="ECO:0000259|Pfam:PF10659" FT REGION 412..447 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 116..143 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 412..427 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 512 AA; 54383 MW; 296F09B378963415 CRC64; MTKLMYLAAT AAMIFHGSSV GQAADDQEAE NAQEFGALCN LIQLASKGFD STEIKINNKL TELETDIQRA EILAYENKTE IDKRAKEGTE GLKKGDKALP QTANGIAAAQ KINETAKAAA ALISALKDKI KKVEAETATA NKHLYKAVWG KEEKPPALKP GAALFAGANA SSIFGDTSSN TRTSNCGGSQ FSSQSDTNVG KTLINDLVCI CIDGQTGMKN CATAAHGTTT NQNNFRTPHS TIHTSWDTLM AECPQTPTKV TAAALQAALT SLVSLIGGNT HSKTTPTQNN KYILGWADAT ATGCDGTTKQ ICVNYAPWQK TVGNSEIRWQ TEVRQGIEAA PTAATESDIT ATINTLTTMN LSVWHLYEAG FASASTVKGE PTKEKIPPIA QEECNKHKSK KTCEEKNCKW EAKGGKSDTE GECKPKPEAE TTAPGAGETT KEGAATTGCA KHGTDKAACL AEKKDDRPVC AFRTGKDGEP EPNKEMCRNG SFLVNKKFAL SVVSAAFVAL LF //