ID   A3R785_9TRYP            Unreviewed;       512 AA.
AC   A3R785;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Variant surface glycoprotein {ECO:0000313|EMBL:ABN70727.1};
GN   Name=VSG {ECO:0000313|EMBL:ABN70727.1};
OS   Trypanosoma brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5691 {ECO:0000313|EMBL:ABN70727.1};
RN   [1] {ECO:0000313|EMBL:ABN70727.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TREU 927 {ECO:0000313|EMBL:ABN70727.1};
RX   PubMed=17652423; DOI=10.1101/gr.6421207;
RA   Marcello L., Barry J.D.;
RT   "Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that
RT   mosaic gene expression is prominent in antigenic variation and is favored
RT   by archive substructure.";
RL   Genome Res. 17:1344-1352(2007).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC       {ECO:0000256|ARBA:ARBA00002523}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC       Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC       {ECO:0000256|ARBA:ARBA00004589}.
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DR   EMBL; EF174490; ABN70727.1; -; mRNA.
DR   AlphaFoldDB; A3R785; -.
DR   VEuPathDB; TriTrypDB:Tb427_000435800; -.
DR   VEuPathDB; TriTrypDB:Tb927.11.20570; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025932; Trypano_VSG_B_N_dom.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
DR   Pfam; PF13206; VSG_B; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..512
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002658004"
FT   DOMAIN          88..354
FT                   /note="Trypanosome variant surface glycoprotein B-type N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13206"
FT   DOMAIN          394..511
FT                   /note="Trypanosome variant surface glycoprotein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10659"
FT   REGION          412..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          116..143
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        412..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  54383 MW;  296F09B378963415 CRC64;
     MTKLMYLAAT AAMIFHGSSV GQAADDQEAE NAQEFGALCN LIQLASKGFD STEIKINNKL
     TELETDIQRA EILAYENKTE IDKRAKEGTE GLKKGDKALP QTANGIAAAQ KINETAKAAA
     ALISALKDKI KKVEAETATA NKHLYKAVWG KEEKPPALKP GAALFAGANA SSIFGDTSSN
     TRTSNCGGSQ FSSQSDTNVG KTLINDLVCI CIDGQTGMKN CATAAHGTTT NQNNFRTPHS
     TIHTSWDTLM AECPQTPTKV TAAALQAALT SLVSLIGGNT HSKTTPTQNN KYILGWADAT
     ATGCDGTTKQ ICVNYAPWQK TVGNSEIRWQ TEVRQGIEAA PTAATESDIT ATINTLTTMN
     LSVWHLYEAG FASASTVKGE PTKEKIPPIA QEECNKHKSK KTCEEKNCKW EAKGGKSDTE
     GECKPKPEAE TTAPGAGETT KEGAATTGCA KHGTDKAACL AEKKDDRPVC AFRTGKDGEP
     EPNKEMCRNG SFLVNKKFAL SVVSAAFVAL LF
//