ID A3R3G8_SCALA Unreviewed; 35 AA. AC A3R3G8; DT 03-APR-2007, integrated into UniProtKB/TrEMBL. DT 03-APR-2007, sequence version 1. DT 27-NOV-2024, entry version 24. DE RecName: Full=Surfactant protein C {ECO:0000256|ARBA:ARBA00044778}; DE AltName: Full=Pulmonary surfactant-associated protein C {ECO:0000256|ARBA:ARBA00044825}; DE Flags: Fragment; GN Name=SP-C {ECO:0000313|EMBL:ABO13942.1}; OS Scapanus latimanus (Broad-footed mole) (Scapanus anthonyi). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Scapanus. OX NCBI_TaxID=182673 {ECO:0000313|EMBL:ABO13942.1}; RN [1] {ECO:0000313|EMBL:ABO13942.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ABTC81026 {ECO:0000313|EMBL:ABO13942.1}; RX PubMed=17568982; DOI=10.1007/s00239-006-0083-1; RA Foot N.J., Orgeig S., Donnellan S., Bertozzi T., Daniels C.B.; RT "Positive selection in the N-terminal extramembrane domain of lung RT surfactant protein C (SP-C) in marine mammals."; RL J. Mol. Evol. 65:12-22(2007). CC -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar CC stability by lowering the surface tension at the air-liquid interface CC in the peripheral air spaces. {ECO:0000256|ARBA:ARBA00002263}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film CC {ECO:0000256|ARBA:ARBA00004364}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF094871; ABO13942.1; -; Genomic_DNA. DR AlphaFoldDB; A3R3G8; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW. DR InterPro; IPR015091; Surfactant_protein_propep. DR Pfam; PF08999; SP_C-Propep; 1. PE 4: Predicted; KW Gaseous exchange {ECO:0000256|ARBA:ARBA00022713}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Surface film {ECO:0000256|ARBA:ARBA00022439}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..35 FT /note="Surfactant protein C N-terminal propeptide" FT /evidence="ECO:0000259|Pfam:PF08999" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABO13942.1" FT NON_TER 35 FT /evidence="ECO:0000313|EMBL:ABO13942.1" SQ SEQUENCE 35 AA; 3715 MW; C8BAB6A0021020FE CRC64; FGIPCCPLRL KRLLIVVVVV VLVVVVIVGA LLMGL //