ID A3PJQ3_RHOS1 Unreviewed; 225 AA. AC A3PJQ3; DT 03-APR-2007, integrated into UniProtKB/TrEMBL. DT 03-APR-2007, sequence version 1. DT 10-JUL-2007, entry version 4. DE 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DE (EC 2.7.7.60). GN OrderedLocusNames=Rsph17029_1459; OS Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; OC Rhodobacteraceae; Rhodobacter. OX NCBI_TaxID=349101; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., RA Mikhailova N., Richardson P., Mackenzie C., Choudhary M., RA Donohue T.J., Kaplan S.; RT "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC RT 17029."; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C- CC methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- CC phosphate (MEP) (By similarity). CC -!- CATALYTIC ACTIVITY: CTP + 2-C-methyl-D-erythritol 4-phosphate = CC diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via CC DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate: CC step 2. CC -!- SIMILARITY: Belongs to the ispD family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000577; ABN76569.1; -; Genomic_DNA. DR InterPro; IPR001228; ISPD_synthase. DR Pfam; PF01128; IspD; 1. DR TIGRFAMs; TIGR00453; ispD; 1. DR PROSITE; PS01295; ISPD; 1. KW Complete proteome; Isoprene biosynthesis; Nucleotidyltransferase; KW Transferase. SQ SEQUENCE 225 AA; 23026 MW; 04558F8E98AA89FE CRC64; MTTAAIIVAA GRGTRAGGDL PKQWQPLAGR PVLAHTLAAF RAAAGVSRTL LVIHPDDRAR AEALPGVAEG KVELVEGGAS RDASVRNALE ALAGAGIERV LIHDGARPLV APGLIARTLA ALETAPGAAP AVPVSDALWR GEGGRVVGTQ DRTGLFRAQT PQAFRYEAIL AAHRAHPGGA ADDVEVARAA GLEVAIVEGC EDNLKVTYPG DFARAERLLA LAAGL //