ID A3E4B0_MOUSE Unreviewed; 227 AA. AC A3E4B0; DT 20-MAR-2007, integrated into UniProtKB/TrEMBL. DT 20-MAR-2007, sequence version 1. DT 18-JAN-2017, entry version 75. DE RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|RuleBase:RU000457}; GN Name=COX2 {ECO:0000313|EMBL:ABH09672.1}; GN Synonyms=COXII {ECO:0000313|EMBL:ABK79265.1}; OS Mus musculus musculus (eastern European house mouse). OG Mitochondrion {ECO:0000313|EMBL:ABH09672.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=39442 {ECO:0000313|EMBL:ABH09672.1}; RN [1] {ECO:0000313|EMBL:ABK79265.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PWD/PhJ {ECO:0000313|EMBL:ABK79265.1}; RX PubMed=17284675; DOI=10.1101/gr.5941007; RA Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.; RT "mtDNA phylogeny and evolution of laboratory mouse strains."; RL Genome Res. 17:293-298(2007). RN [2] {ECO:0000313|EMBL:ABH09672.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PWD/Ph {ECO:0000313|EMBL:ABH09672.1}; RX PubMed=18256238; DOI=10.1101/gr.7160508; RA Gregorova S., Divina P., Storchova R., Trachtulec Z., Fotopulosova V., RA Svenson K.L., Donahue L.R., Paigen B., Forejt J.; RT "Mouse consomic strains: exploiting genetic divergence between Mus m. RT musculus and Mus m. domesticus subspecies."; RL Genome Res. 18:509-515(2008). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. Subunit 2 CC transfers the electrons from cytochrome c via its binuclear copper CC A center to the bimetallic center of the catalytic subunit 1. CC {ECO:0000256|RuleBase:RU000457}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00278826}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00278826}. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family. CC {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00552932}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ874614; ABH09672.1; -; Genomic_DNA. DR EMBL; EF108343; ABK79265.1; -; Genomic_DNA. DR RefSeq; YP_001686701.1; NC_010339.1. DR ProteinModelPortal; A3E4B0; -. DR PRIDE; A3E4B0; -. DR GeneID; 5912281; -. DR CTD; 4513; -. DR HOVERGEN; HBG012727; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0005507; F:copper ion binding; IEA:InterPro. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:InterPro. DR Gene3D; 1.10.287.90; -; 1. DR Gene3D; 2.60.40.420; -; 1. DR InterPro; IPR002429; CcO_II-like_C. DR InterPro; IPR001505; Copper_CuA. DR InterPro; IPR008972; Cupredoxin. DR InterPro; IPR014222; Cyt_c_oxidase_su2. DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom. DR Pfam; PF00116; COX2; 1. DR Pfam; PF02790; COX2_TM; 1. DR SUPFAM; SSF49503; SSF49503; 1. DR SUPFAM; SSF81464; SSF81464; 1. DR TIGRFAMs; TIGR02866; CoxB; 1. DR PROSITE; PS00078; COX2; 1. DR PROSITE; PS50857; COX2_CUA; 1. DR PROSITE; PS50999; COX2_TM; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00515163}; KW Electron transport {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00644428}; KW Membrane {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00644354, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00515158}; KW Mitochondrion {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00278823, ECO:0000313|EMBL:ABH09672.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00278827}; KW Oxidoreductase {ECO:0000313|EMBL:ABK79265.1}; KW Respiratory chain {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00044966}; KW Transmembrane {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00106619, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00106576, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000457, KW ECO:0000256|SAAS:SAAS00644342}. FT TRANSMEM 27 46 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 66 85 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 91 COX2_TM. {ECO:0000259|PROSITE:PS50999}. FT DOMAIN 92 225 COX2_CUA. {ECO:0000259|PROSITE:PS50857}. SQ SEQUENCE 227 AA; 25946 MW; 306C7FAD54912D11 CRC64; MAYPFQLGLQ DATSPIMEEL MNFHDHTLMI VFLISSLVLY IISLMLTTKL THTSTMDAQE VETIWTILPA VILIMIALPS LRILYMMDEI NNPVLTVKTM GHQWYWSYEY TDYEDLCFDS YMIPTNDLKP GELRLLEVDN RVVLPMELPI RMLISSEDVL HSWAVPSLGL KTDAIPGRLN QATVASNRPG LFYGQCSEIC GSNHSFMPIV LEMVPLKYFE NWSASMI //