ID G6PI_CLOTH Reviewed; 448 AA. AC A3DBX9; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-2007, sequence version 1. DT 14-MAY-2014, entry version 44. DE RecName: Full=Glucose-6-phosphate isomerase; DE Short=GPI; DE EC=5.3.1.9; DE AltName: Full=Phosphoglucose isomerase; DE Short=PGI; DE AltName: Full=Phosphohexose isomerase; DE Short=PHI; GN Name=pgi; OrderedLocusNames=Cthe_0217; OS Clostridium thermocellum (strain ATCC 27405 / DSM 1237). OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; OC Clostridium. OX NCBI_TaxID=203119; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 27405 / DSM 1237; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., RA Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., RA Mikhailova N., Wu J.H.D., Newcomb M., Richardson P.; RT "Complete sequence of Clostridium thermocellum ATCC 27405."; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6- CC phosphate. CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 2/4. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the GPI family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000568; ABN51458.1; -; Genomic_DNA. DR RefSeq; YP_001036651.1; NC_009012.1. DR ProteinModelPortal; A3DBX9; -. DR SMR; A3DBX9; 4-448. DR STRING; 203119.Cthe_0217; -. DR EnsemblBacteria; ABN51458; ABN51458; Cthe_0217. DR GeneID; 4808635; -. DR KEGG; cth:Cthe_0217; -. DR PATRIC; 19514067; VBICloThe47081_0232. DR eggNOG; COG0166; -. DR HOGENOM; HOG000100403; -. DR KO; K01810; -. DR OMA; LANFNPK; -. DR OrthoDB; EOG64R61J; -. DR BioCyc; CTHE203119:GIW8-223-MONOMER; -. DR UniPathway; UPA00109; UER00181. DR UniPathway; UPA00138; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-HAMAP. DR GO; GO:0006096; P:glycolysis; IEA:UniProtKB-HAMAP. DR HAMAP; MF_00473; G6P_isomerase; 1. DR InterPro; IPR001672; G6P_Isomerase. DR InterPro; IPR018189; Phosphoglucose_isomerase_CS. DR PANTHER; PTHR11469; PTHR11469; 1. DR Pfam; PF00342; PGI; 1. DR PRINTS; PR00662; G6PISOMERASE. DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1. DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1. DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase. FT CHAIN 1 448 Glucose-6-phosphate isomerase. FT /FTId=PRO_1000013960. FT ACT_SITE 290 290 Proton donor (By similarity). FT ACT_SITE 311 311 By similarity. FT ACT_SITE 425 425 By similarity. SQ SEQUENCE 448 AA; 50287 MW; C2B06430611EFE7F CRC64; MERIKFDYSK ALPFVSEREV AYFENFVRSA HDMLHNKTGA GNDFVGWVDL PVNYDREEFA RIKAAAEKIK SDSDALVVIG IGGSYLGARA AIEMLSHSFH NLMPKSKRNA PEIYFVGNNI SSTYIADLLE VIEGKEISVN VISKSGTTTE PAIAFRIFKE YMENKYGKDG ASKRIYATTD KEKGALRKLA TEEGYETFVV PDDIGGRFSV LTAVGLLPIA VAGIDIDSMM KGAADARELY SNPNLMENDC YKYAAVRNAL YRKNKTIEIM VNYEPSLHYF TEWWKQLYGE SEGKDQKGIF PAGVDFTTDL HSMGQYIQDG LRNIFETVIR VEKPRKNIVI KEEKDNLDGL NFIAGKDVDY VNKKAMEGTV LAHTDGGVPN LVVTVPELSA YYFGNMVYFF EKACGISGYL LGVNPFDQPG VEAYKKNMFA LLGKPGYEEQ RKKLEERL //