ID   G6PI_CLOTH              Reviewed;         448 AA.
AC   A3DBX9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   19-JAN-2010, entry version 22.
DE   RecName: Full=Glucose-6-phosphate isomerase;
DE            Short=GPI;
DE            EC=5.3.1.9;
DE   AltName: Full=Phosphoglucose isomerase;
DE            Short=PGI;
DE   AltName: Full=Phosphohexose isomerase;
DE            Short=PHI;
GN   Name=pgi; OrderedLocusNames=Cthe_0217;
OS   Clostridium thermocellum (strain ATCC 27405 / DSM 1237).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=203119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Wu J.H.D., Newcomb M., Richardson P.;
RT   "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the GPI family.
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DR   EMBL; CP000568; ABN51458.1; -; Genomic_DNA.
DR   RefSeq; YP_001036651.1; -.
DR   SMR; A3DBX9; 4-448.
DR   STRING; A3DBX9; -.
DR   GeneID; 4808635; -.
DR   GenomeReviews; CP000568_GR; Cthe_0217.
DR   KEGG; cth:Cthe_0217; -.
DR   NMPDR; fig|203119.1.peg.2302; -.
DR   eggNOG; COG0166; -.
DR   HOGENOM; HBG615843; -.
DR   OMA; NPRKNVI; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00473; G6P_isomerase; 1; -.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   PANTHER; PTHR11469; G6P_Isomerase; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase.
FT   CHAIN         1    448       Glucose-6-phosphate isomerase.
FT                                /FTId=PRO_1000013960.
FT   ACT_SITE    290    290       Proton donor (By similarity).
FT   ACT_SITE    311    311       By similarity.
FT   ACT_SITE    425    425       By similarity.
SQ   SEQUENCE   448 AA;  50287 MW;  C2B06430611EFE7F CRC64;
     MERIKFDYSK ALPFVSEREV AYFENFVRSA HDMLHNKTGA GNDFVGWVDL PVNYDREEFA
     RIKAAAEKIK SDSDALVVIG IGGSYLGARA AIEMLSHSFH NLMPKSKRNA PEIYFVGNNI
     SSTYIADLLE VIEGKEISVN VISKSGTTTE PAIAFRIFKE YMENKYGKDG ASKRIYATTD
     KEKGALRKLA TEEGYETFVV PDDIGGRFSV LTAVGLLPIA VAGIDIDSMM KGAADARELY
     SNPNLMENDC YKYAAVRNAL YRKNKTIEIM VNYEPSLHYF TEWWKQLYGE SEGKDQKGIF
     PAGVDFTTDL HSMGQYIQDG LRNIFETVIR VEKPRKNIVI KEEKDNLDGL NFIAGKDVDY
     VNKKAMEGTV LAHTDGGVPN LVVTVPELSA YYFGNMVYFF EKACGISGYL LGVNPFDQPG
     VEAYKKNMFA LLGKPGYEEQ RKKLEERL
//