ID KCY_METMJ Reviewed; 181 AA. AC A3CT23; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-2007, sequence version 1. DT 12-OCT-2022, entry version 80. DE RecName: Full=Cytidylate kinase {ECO:0000255|HAMAP-Rule:MF_00239}; DE Short=CK {ECO:0000255|HAMAP-Rule:MF_00239}; DE EC=2.7.4.25 {ECO:0000255|HAMAP-Rule:MF_00239}; DE AltName: Full=Cytidine monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_00239}; DE Short=CMP kinase {ECO:0000255|HAMAP-Rule:MF_00239}; GN Name=cmk {ECO:0000255|HAMAP-Rule:MF_00239}; OrderedLocusNames=Memar_0590; OS Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1). OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus. OX NCBI_TaxID=368407; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 35101 / DSM 1498 / JR1; RX PubMed=21304656; DOI=10.4056/sigs.32535; RA Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., RA Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.; RT "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 RT type strain JR1."; RL Stand. Genomic Sci. 1:189-196(2009). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377, CC ChEBI:CHEBI:456216; EC=2.7.4.25; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00239}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593, CC ChEBI:CHEBI:456216; EC=2.7.4.25; Evidence={ECO:0000255|HAMAP- CC Rule:MF_00239}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00239}. CC -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 2 subfamily. CC {ECO:0000255|HAMAP-Rule:MF_00239}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000562; ABN56523.1; -; Genomic_DNA. DR RefSeq; WP_011843433.1; NC_009051.1. DR AlphaFoldDB; A3CT23; -. DR SMR; A3CT23; -. DR STRING; 368407.Memar_0590; -. DR EnsemblBacteria; ABN56523; ABN56523; Memar_0590. DR GeneID; 4847872; -. DR KEGG; mem:Memar_0590; -. DR eggNOG; arCOG01037; Archaea. DR HOGENOM; CLU_079959_1_0_2; -. DR OMA; ADFRFWL; -. DR OrthoDB; 110333at2157; -. DR Proteomes; UP000002146; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0036430; F:CMP kinase activity; IEA:RHEA. DR GO; GO:0036431; F:dCMP kinase activity; IEA:RHEA. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0006220; P:pyrimidine nucleotide metabolic process; IEA:UniProtKB-UniRule. DR CDD; cd02020; CMPK; 1. DR Gene3D; 3.40.50.300; -; 1. DR HAMAP; MF_00239; Cytidyl_kinase_type2; 1. DR InterPro; IPR011892; Cyt_kin_arch. DR InterPro; IPR011994; Cytidylate_kinase_dom. DR InterPro; IPR027417; P-loop_NTPase. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR02173; cyt_kin_arch; 1. PE 3: Inferred from homology; KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase. FT CHAIN 1..181 FT /note="Cytidylate kinase" FT /id="PRO_1000005677" FT BINDING 7..15 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00239" SQ SEQUENCE 181 AA; 19728 MW; 185677D3E408D726 CRC64; MRITISGPPG SGTTSLARYL AGKHGLDLIS AGEVFRQLAK EHGMDLADFG KFAENDPSVD RMIDARQKEI GEAAENIIIE GRLSGRMVGN ADLRIWLSAS LSCRARRIAG RDGMDEEGAR AYTENRQRSE ATRYRNYYGI EIDDLSPYDI VLSSETFGVD ALGTIVDAAI ACLARQQAAD L //