ID A2SKS8_METPP Unreviewed; 971 AA. AC A2SKS8; DT 06-MAR-2007, integrated into UniProtKB/TrEMBL. DT 06-MAR-2007, sequence version 1. DT 16-APR-2014, entry version 57. DE RecName: Full=Ribonucleoside-diphosphate reductase; DE EC=1.17.4.1; GN OrderedLocusNames=Mpe_A3214; OS Methylibium petroleiphilum (strain PM1). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Methylibium. OX NCBI_TaxID=420662; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PM1; RX PubMed=17158667; DOI=10.1128/JB.01259-06; RA Kane S.R., Chakicherla A.Y., Chain P.S., Schmidt R., Shin M.W., RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M., RA Hristova K.R.; RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta- RT proteobacterium Methylibium petroleiphilum PM1."; RL J. Bacteriol. 189:1931-1945(2007). CC -!- FUNCTION: Provides the precursors necessary for DNA synthesis. CC Catalyzes the biosynthesis of deoxyribonucleotides from the CC corresponding ribonucleotides (By similarity). CC -!- CATALYTIC ACTIVITY: 2'-deoxyribonucleoside diphosphate + CC thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + CC thioredoxin. CC -!- PATHWAY: Genetic information processing; DNA replication. CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase CC large chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000555; ABM96167.1; -; Genomic_DNA. DR RefSeq; YP_001022402.1; NC_008825.1. DR ProteinModelPortal; A2SKS8; -. DR STRING; 420662.Mpe_A3214; -. DR EnsemblBacteria; ABM96167; ABM96167; Mpe_A3214. DR GeneID; 4786553; -. DR KEGG; mpt:Mpe_A3214; -. DR eggNOG; COG0209; -. DR HOGENOM; HOG000057036; -. DR KO; K00525; -. DR OMA; DRYFLHI; -. DR OrthoDB; EOG6J48HC; -. DR ProtClustDB; PRK07207; -. DR BioCyc; MPET420662:GHBE-3251-MONOMER; -. DR UniPathway; UPA00326; -. DR GO; GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. DR InterPro; IPR005144; ATP-cone. DR InterPro; IPR013346; NrdE_NrdA. DR InterPro; IPR000788; RNR_lg_C. DR InterPro; IPR013509; RNR_lsu_N. DR InterPro; IPR008926; RNR_R1-su_N. DR Pfam; PF03477; ATP-cone; 1. DR Pfam; PF02867; Ribonuc_red_lgC; 1. DR Pfam; PF00317; Ribonuc_red_lgN; 1. DR PRINTS; PR01183; RIBORDTASEM1. DR SUPFAM; SSF48168; SSF48168; 1. DR TIGRFAMs; TIGR02506; NrdE_NrdA; 1. DR PROSITE; PS51161; ATP_CONE; 2. DR PROSITE; PS00089; RIBORED_LARGE; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; DNA replication; Nucleotide-binding; KW Oxidoreductase. SQ SEQUENCE 971 AA; 107322 MW; 2922953B61A02799 CRC64; MQSISSSVPA AALAGGALAA TAVSRAAPGS SAYAGYQIIR RNGAVVAFEP NKIAVALMKA FLAVHGTQGA ASASVREMVD GLTESVVRAL LRSRPGGGTF HIEDVQDAVE LGLMRGGHHE IARAYVLYRE RRAQERAKQG AAPVTPAVAL HVIDRGQRVP LDTGRLQALV ESACANLGSE VQAAPILAET QRNLYDGVPI DEVYKAAILA ARTLIEKDPA YTRATARLLL HTIRREILGG EVLHEEMQQR YADYFPGFIK QGVEAELLDE RLMQYDLRRL GEALKADRDL QFDYLGLQTL YDRYFLHVRK ARIELPQAFF MRVAMGLALN EVDREARAIE FYEVLSSFDF MSSTPTLFNS GTRRSQLSSC YLTTVADDLD GIYEAIKENA LLSKFAGGLG NDWTPVRALG SHIKGTNGES QGVVPFLKVV NDTAVAVNQG GKRKGAVCAY LETWHLDIEE FLELRKNTGD DRRRTHDMNT ANWIPDLFMR RVIEGGDWTL FSPSTCPDLH DKFGIAFEQA YTAYEQKADR GELKLYKRVP AKDLWRKMLS MLFETGHPWI TFKDACNVRS PQQHVGVVHS SNLCTEITLN TNGSEIAVCN LGSVNLAQHL MHGAEGLEID HAKLRKTVST AMRMLDNVID INYYAVKKAR DSNLRHRPVG LGVMGFQDSL YQLRIAYASQ QAVEYADRSM EAVCYHAYWA STELAEERGR YSSYKGSLWD RGILPIDSLD LLAEQRGGYV DVDRSTSLDW DALRARIQQH GMRNSNCVAI APTATISNII GVDASIEPSF SNLSVKSNLS GEFTVINEYL VRDLKKLGLW DDVMVMDLKH FDGSLRRIDR VPEELKSLYA TAFEVEPTWL VEAAARRQKW IDQAQSLNIY MAGASGKKLD DTYKLAWQRG LKTTYYLRTV GATHAEKSTV KAGHLNAVSS GSGGVDAVAA AAQAQFDAAS SVPATDMKFC AIDDPTCEAC Q //