ID A2RRF8_HUMAN Unreviewed; 90 AA. AC A2RRF8; DT 06-MAR-2007, integrated into UniProtKB/TrEMBL. DT 06-MAR-2007, sequence version 1. DT 22-JUL-2008, entry version 11. DE SubName: Full=ICEBERG caspase-1 inhibitor; GN Name=ICEBERG; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Contains 1 CARD domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC131610; AAI31611.1; -; mRNA. DR RefSeq; NP_067546.1; -. DR UniGene; Hs.56279; -. DR SMR; A2RRF8; 2-90. DR Ensembl; ENSG00000118168; Homo sapiens. DR GeneID; 59082; -. DR KEGG; hsa:59082; -. DR HOVERGEN; A2RRF8; -. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0030693; F:caspase activity; IEA:InterPro. DR GO; GO:0005515; F:protein binding; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0042981; P:regulation of apoptosis; IEA:InterPro. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH_like. DR InterPro; IPR002398; Pept_C14_p45. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR PANTHER; PTHR10454; Pept_C14_p45; 1. DR Pfam; PF00619; CARD; 1. DR SMART; SM00114; CARD; 1. DR PROSITE; PS50209; CARD; 1. PE 4: Predicted; SQ SEQUENCE 90 AA; 10138 MW; 7E74C74263367101 CRC64; MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH //