ID ATG8_ASPNC Reviewed; 118 AA. AC A2QPN1; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 06-MAR-2007, sequence version 1. DT 20-APR-2010, entry version 25. DE RecName: Full=Autophagy-related protein 8; DE AltName: Full=Autophagy-related ubiquitin-like modifier atg8; DE Flags: Precursor; GN Name=atg8; ORFNames=An07g10020; OS Aspergillus niger (strain CBS 513.88 / FGSC A1513). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Pezizomycotina; OC Leotiomyceta; Eurotiomycetes; Eurotiomycetidae; Eurotiales; OC Trichocomaceae; mitosporic Trichocomaceae; Aspergillus. OX NCBI_TaxID=425011; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17259976; DOI=10.1038/nbt1282; RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., RA Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., RA Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., RA Breestraat S., Caddick M.X., Contreras R., Cornell M., Coutinho P.M., RA Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., RA van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., RA Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., RA Henrissat B., Herweijer M., van den Hombergh J.P.T.W., RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., RA van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., RA van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., RA Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., RA Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., RA Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., RA Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., RA Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.; RT "Genome sequencing and analysis of the versatile cell factory RT Aspergillus niger CBS 513.88."; RL Nat. Biotechnol. 25:221-231(2007). CC -!- FUNCTION: Involved in cytoplasm to vacuole transport (Cvt) CC vesicles and autophagosomes formation. May mediate the delivery of CC the vesicles and autophagosomes to the vacuole via the microtubule CC cytoskeleton (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, cvt vesicle membrane; CC Lipid-anchor (By similarity). Cytoplasmic vesicle, autophagosome CC membrane; Lipid-anchor (By similarity). Vacuole membrane; Lipid- CC anchor (By similarity). Note=Membrane-associated through a lipid CC anchor (By similarity). CC -!- PTM: The C-terminal 2 residues are removed by atg4 to expose Gly- CC 116 at the C-terminus. The c-terminal Gly is then amidated with CC phosphatidylethanolamine by an activating system similar to that CC for ubiquitin (By similarity). CC -!- SIMILARITY: Belongs to the MAP1 LC3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM270155; CAK45131.1; -; Genomic_DNA. DR RefSeq; XP_001392077.1; -. DR SMR; A2QPN1; 1-113. DR GeneID; 4982271; -. DR GenomeReviews; AM270986_GR; atg8. DR KEGG; ang:An07g10020; -. DR HOGENOM; HBG592694; -. DR OrthoDB; EOG9ZKM3X; -. DR GO; GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell. DR GO; GO:0033110; C:CVT vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR InterPro; IPR004241; MAP1_LC3. DR PANTHER; PTHR10969; MAP1_LC3; 1. DR Pfam; PF02991; MAP1_LC3; 1. PE 3: Inferred from homology; KW Autophagy; Complete proteome; Cytoplasmic vesicle; Lipoprotein; KW Membrane; Protein transport; Transport; Ubl conjugation pathway; KW Vacuole. FT CHAIN 1 116 Autophagy-related protein 8. FT /FTId=PRO_0000317876. FT PROPEP 117 118 Removed in mature form (By similarity). FT /FTId=PRO_0000317877. FT LIPID 116 116 Phosphatidylethanolamine amidated glycine FT (By similarity). SQ SEQUENCE 118 AA; 13738 MW; 85E8807255E14793 CRC64; MRSKFKDEHP FEKRKAEAER IRQKYADRIP VICEKVEKSD IATIDKKKYL VPADLTVGQF VYVIRKRIKL SPEKAIFIFV DEVLPPTAAL MSSIYEEHKD EDGFLYITYS GENTFGDC //