ID A2I2P6_HUMAN Unreviewed; 1281 AA. AC A2I2P6; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 14-DEC-2022, entry version 71. DE SubName: Full=Period 1 {ECO:0000313|EMBL:ABM64215.1}; GN Name=PER1 {ECO:0000313|EMBL:ABM64215.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABM64215.1}; RN [1] {ECO:0000313|EMBL:ABM64215.1} RP NUCLEOTIDE SEQUENCE. RA Kripke D.F., Klimecki W.; RT "PER1 Resequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF015904; ABM64215.1; -; Genomic_DNA. DR PeptideAtlas; A2I2P6; -. DR ChiTaRS; PER1; human. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW. DR CDD; cd00130; PAS; 1. DR InterPro; IPR000014; PAS. DR InterPro; IPR035965; PAS-like_dom_sf. DR InterPro; IPR013655; PAS_fold_3. DR InterPro; IPR022728; Period_circadian-like_C. DR Pfam; PF08447; PAS_3; 1. DR Pfam; PF12114; Period_C; 1. DR SMART; SM00091; PAS; 2. DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1. DR PROSITE; PS50112; PAS; 1. PE 4: Predicted; KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}. FT DOMAIN 364..407 FT /note="PAS" FT /evidence="ECO:0000259|PROSITE:PS50112" FT REGION 1..134 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 499..535 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 556..592 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 637..689 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 740..763 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 796..865 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 929..968 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 987..1028 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1042..1089 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1198..1281 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 21..37 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 43..134 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 637..661 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 742..760 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 818..836 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 848..865 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 938..961 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1281 AA; 135147 MW; 9C64428D601141C3 CRC64; MSGPLEGADG GGDPRPGESF CPGGVPSPGP PQHRPCPGPS LADDTDANSN GSSGNESNGH ESRGASQRSS HSSSSGNGKD SALLETTESS KSTNSQSPSP PSSSIAYSLL SASSEQDNPS TSGCSSEQSA RARTQKELMT ALRELKLRLP PERRGKGRSG TLATLQYALA CVKQVQANQE YYQQWSLEEG EPCSMDMSTY TLEELEHIDT FSVAVSFLTG RIVYISEQAA VLLRCKRDVF RGTRFSELLA PQDVGVFYGS TAPSRLPTWG TGASAGSGLR DFTQEKSVFC RIRGGPDRDP GPRYQPFRLT PYVTKIRVSD GAPAQPCCLL IAERIHSGYE APRIPPDKRI FTTRHTPSCL FQDVDERAAP LLGYLPQDLL GAPVLLFLHP EDRPLMLAIH KKILQLAGQP FDHSPIRFCA RNGEYVTMDT SWAGFVHPWS RKVAFVLGRH KVRTAPLNED VFTPPAPSPA PSLDTDIQEL SEQIHRLLLQ PVHSPSPTGL CGVGAVTSPG PLHSPGSSSD SNGGDAEGPG PPAPVTFQQI CKDVHLVKHQ GQQLFIESRA RPQSRPRLPA TGTFKAKALP CQSPDPELEA GSAPVQAPLA LVPEEAERKE ASSCSYQQIN CLDSILRYLE SCNLPSTTKR KCASSSSYTT SSASDDDRQR TGPVSVGTKK DPPSAALSGE GATPRKEPVV GGTLSPLALA NKAESVVSVT SQCSFSSTIV HVGDKKPPES DIIMMEDLPG LAPGPAPSPA PSPTVAPDPA PDAYRPVGLT KAVLSLHTQK EEQAFLSRFR DLGRLRGLDS SSTAPSALGE RGCHHGPAPP SRRHHCRSKA KRSRHHQNPR AEAPCYVSHP SPVPPSTPWP TPPATTPFPA VVQPYPLPVF SPRGGPQPLP PAPTSVPPAA FPAPLVTPMV ALVLPNYLFP TPSSYPYGAL QTPAEGPPTP ASHSPSPSLP ALAPSPPHRP DSPLFNSRCS SPLQLNLLQL EELPRAEGAA VAGGPGSSAG PPPPSAEAAE PEARLAEVTE SSNQDALSGS SDLLELLLQE DSRSGTGSAA SGSLGSGLGS GSGSGSHEGG STSASITRSS QSSHTSKYFG SIDSSEAEAG AARGGAEPGD QVIKYVLQDP IWLLMANADQ RVMMTYQVPS RDMTSVLKQD RERLRAMQKQ QPRFSEDQRR ELGAVHSWVR KGQLPRALDV MACVDCGSST QDPGHPDDPL FSELDGLGLE PMEEGGGEQG SSGGGSGEGE GCEEAQGGAK ASSSQDLAME EEEEGRSSSS PALPTAGNCT S //