ID A2DKY5_TRIV3 Unreviewed; 180 AA. AC A2DKY5; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 24-JAN-2024, entry version 72. DE SubName: Full=Transcriptional regulator, Sir2 family protein {ECO:0000313|EMBL:EAY18938.1}; GN ORFNames=TVAG_146810 {ECO:0000313|EMBL:EAY18938.1}; OS Trichomonas vaginalis (strain ATCC PRA-98 / G3). OC Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae; OC Trichomonas. OX NCBI_TaxID=412133 {ECO:0000313|EMBL:EAY18938.1, ECO:0000313|Proteomes:UP000001542}; RN [1] {ECO:0000313|EMBL:EAY18938.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=G3 {ECO:0000313|EMBL:EAY18938.1}; RA Amadeo P., Zhao Q., Wortman J., Fraser-Liggett C., Carlton J.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EAY18938.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=G3 {ECO:0000313|EMBL:EAY18938.1}; RX PubMed=17218520; DOI=10.1126/science.1132894; RA Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., RA Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., RA Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., RA Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S., RA Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., RA Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., RA Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., RA Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., RA Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., RA Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., RA Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., RA Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., RA Johnson P.J.; RT "Draft genome sequence of the sexually transmitted pathogen Trichomonas RT vaginalis."; RL Science 315:207-212(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS113213; EAY18938.1; -; Genomic_DNA. DR RefSeq; XP_001579924.1; XM_001579874.1. DR AlphaFoldDB; A2DKY5; -. DR STRING; 5722.A2DKY5; -. DR GeneID; 5464455; -. DR KEGG; tva:TVAG_2v0362020; -. DR VEuPathDB; TrichDB:TVAG_409810; -. DR VEuPathDB; TrichDB:TVAGG3_0362020; -. DR eggNOG; KOG2682; Eukaryota. DR InParanoid; A2DKY5; -. DR OMA; MNECLSA; -. DR Proteomes; UP000001542; Unassembled WGS sequence. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0070403; F:NAD+ binding; IBA:GO_Central. DR GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IBA:GO_Central. DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.1220; TPP-binding domain; 1. DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom. DR InterPro; IPR003000; Sirtuin. DR InterPro; IPR026590; Ssirtuin_cat_dom. DR PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1. DR PANTHER; PTHR47651:SF11; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2; 1. DR Pfam; PF02146; SIR2; 1. DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1. DR PROSITE; PS50305; SIRTUIN; 1. PE 4: Predicted; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Reference proteome {ECO:0000313|Proteomes:UP000001542}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}. FT DOMAIN 1..180 FT /note="Deacetylase sirtuin-type" FT /evidence="ECO:0000259|PROSITE:PS50305" FT ACT_SITE 133 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 141 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 144 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 176 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" FT BINDING 179 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" SQ SEQUENCE 180 AA; 20538 MW; 268AD6F7ABDB6407 CRC64; MNQNISVLAN LLKSGNYKNV VVMTGSGICN ACGIPDLHSI IPDLNKKAEE TGFTPYMTPP FVFDIRFFRE NPKPFWWVFS EIWPWNEMPL PTDFHILIRL IEEMGLLRRW YTTNTDCLEL DAIKDKSKVV QCHGSVKHCH CIDCGAEVSM NECLSAIRGN YGRKEKGFDF VKVPTCNKCG //