ID   A2DKY5_TRIV3            Unreviewed;       180 AA.
AC   A2DKY5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   03-MAY-2023, entry version 69.
DE   SubName: Full=Transcriptional regulator, Sir2 family protein {ECO:0000313|EMBL:EAY18938.1};
GN   ORFNames=TVAG_146810 {ECO:0000313|EMBL:EAY18938.1};
OS   Trichomonas vaginalis (strain ATCC PRA-98 / G3).
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=412133 {ECO:0000313|EMBL:EAY18938.1};
RN   [1] {ECO:0000313|EMBL:EAY18938.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY18938.1};
RA   Amadeo P., Zhao Q., Wortman J., Fraser-Liggett C., Carlton J.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAY18938.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY18938.1};
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S.,
RA   Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D.,
RA   Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y.,
RA   Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M.,
RA   Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J.,
RA   Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B.,
RA   Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A.,
RA   Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S.,
RA   Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen Trichomonas
RT   vaginalis.";
RL   Science 315:207-212(2007).
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DR   EMBL; DS113213; EAY18938.1; -; Genomic_DNA.
DR   RefSeq; XP_001579924.1; XM_001579874.1.
DR   AlphaFoldDB; A2DKY5; -.
DR   STRING; 5722.XP_001579924.1; -.
DR   GeneID; 5464455; -.
DR   KEGG; tva:TVAG_2v0362020; -.
DR   VEuPathDB; TrichDB:TVAG_409810; -.
DR   VEuPathDB; TrichDB:TVAGG3_0362020; -.
DR   eggNOG; KOG2682; Eukaryota.
DR   InParanoid; A2DKY5; -.
DR   OMA; MNECLSA; -.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070403; F:NAD+ binding; IBA:GO_Central.
DR   GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IBA:GO_Central.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR47651; NAD-DEPENDENT HISTONE DEACETYLASE HST4; 1.
DR   PANTHER; PTHR47651:SF11; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..180
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
SQ   SEQUENCE   180 AA;  20538 MW;  268AD6F7ABDB6407 CRC64;
     MNQNISVLAN LLKSGNYKNV VVMTGSGICN ACGIPDLHSI IPDLNKKAEE TGFTPYMTPP
     FVFDIRFFRE NPKPFWWVFS EIWPWNEMPL PTDFHILIRL IEEMGLLRRW YTTNTDCLEL
     DAIKDKSKVV QCHGSVKHCH CIDCGAEVSM NECLSAIRGN YGRKEKGFDF VKVPTCNKCG
//