ID   A2DKY5_TRIVA            Unreviewed;       180 AA.
AC   A2DKY5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   20-MAY-2008, entry version 14.
DE   Transcriptional regulator, Sir2 family protein.
GN   ORFNames=TVAG_146810;
OS   Trichomonas vaginalis G3.
OC   Eukaryota; Parabasalidea; Trichomonada; Trichomonadida;
OC   Trichomonadidae; Trichomonadinae; Trichomonas.
OX   NCBI_TaxID=412133;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=G3;
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D.,
RA   Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H.,
RA   Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D.,
RA   Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S.,
RA   Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R.,
RA   Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L.,
RA   Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K.,
RA   Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O.,
RA   Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M.,
RA   Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen
RT   Trichomonas vaginalis.";
RL   Science 315:207-212(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=G3;
RA   Amadeo P., Zhao Q., Wortman J., Fraser-Liggett C., Carlton J.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: NAD(+) + an acetylprotein = nicotinamide + O-
CC       acetyl-ADP-ribose + a protein.
CC   -!- SIMILARITY: Contains 1 deacetylase sirtuin-type domain.
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DR   EMBL; DS113213; EAY18938.1; -; Genomic_DNA.
DR   RefSeq; XP_001579924.1; -.
DR   GeneID; 5464455; -.
DR   KEGG; tva:TVAG_146810; -.
DR   GO; GO:0005677; C:chromatin silencing complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006342; P:chromatin silencing; IEA:InterPro.
DR   GO; GO:0006476; P:protein amino acid deacetylation; IEA:InterPro.
DR   InterPro; IPR003000; NAD-dep_histone_deAcase_SIR2.
DR   PANTHER; PTHR11085; SIR2; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Hydrolase; NAD.
SQ   SEQUENCE   180 AA;  20538 MW;  268AD6F7ABDB6407 CRC64;
     MNQNISVLAN LLKSGNYKNV VVMTGSGICN ACGIPDLHSI IPDLNKKAEE TGFTPYMTPP
     FVFDIRFFRE NPKPFWWVFS EIWPWNEMPL PTDFHILIRL IEEMGLLRRW YTTNTDCLEL
     DAIKDKSKVV QCHGSVKHCH CIDCGAEVSM NECLSAIRGN YGRKEKGFDF VKVPTCNKCG
//