ID A2C604_PROM3 Unreviewed; 135 AA. AC A2C604; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 02-DEC-2020, entry version 69. DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN Name=crcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN OrderedLocusNames=P9303_01591 {ECO:0000313|EMBL:ABM76914.1}; OS Prochlorococcus marinus (strain MIT 9303). OC Bacteria; Cyanobacteria; Synechococcales; Prochloraceae; Prochlorococcus. OX NCBI_TaxID=59922 {ECO:0000313|EMBL:ABM76914.1, ECO:0000313|Proteomes:UP000002274}; RN [1] {ECO:0000313|EMBL:ABM76914.1, ECO:0000313|Proteomes:UP000002274} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MIT 9303 {ECO:0000313|EMBL:ABM76914.1, RC ECO:0000313|Proteomes:UP000002274}; RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231; RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., RA Richardson P., Chisholm S.W.; RT "Patterns and implications of gene gain and loss in the evolution of RT Prochlorococcus."; RL PLoS Genet. 3:2515-2528(2007). CC -!- FUNCTION: Important for reducing fluoride concentration in the cell, CC thus reducing its toxicity. {ECO:0000256|ARBA:ARBA00004023, CC ECO:0000256|HAMAP-Rule:MF_00454}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_00454}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass CC membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. CC {ECO:0000256|ARBA:ARBA00007610, ECO:0000256|HAMAP-Rule:MF_00454}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000554; ABM76914.1; -; Genomic_DNA. DR EnsemblBacteria; ABM76914; ABM76914; P9303_01591. DR KEGG; pmf:P9303_01591; -. DR HOGENOM; CLU_114342_2_3_3; -. DR OMA; HFEPMVP; -. DR Proteomes; UP000002274; Chromosome. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:UniProtKB-UniRule. DR HAMAP; MF_00454; CrcB; 1. DR InterPro; IPR003691; CrcB. DR PANTHER; PTHR28259; PTHR28259; 1. DR Pfam; PF02537; CRCB; 1. PE 3: Inferred from homology; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00454}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_00454}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00454}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_00454}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_00454}; Transport {ECO:0000256|HAMAP-Rule:MF_00454}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 45..65 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 77..100 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 112..133 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" SQ SEQUENCE 135 AA; 13803 MW; 3E9CE0E61D1D9A5C CRC64; MAGSMSDLAL PAWQASLVAI GAVPGAWLRL RVVNHLEPMV PRKHWGTFAV NMVAAFALGL VLALQAKCAP ASGASPLILL IGVGFFGSLS TFSTFAGEVL NTLREHRWSE ALVLAVGSIL GGLLAVAAGV GLADG //