ID A2C604_PROM3 Unreviewed; 135 AA. AC A2C604; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 25-OCT-2017, entry version 63. DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN Name=crcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN OrderedLocusNames=P9303_01591 {ECO:0000313|EMBL:ABM76914.1}; OS Prochlorococcus marinus (strain MIT 9303). OC Bacteria; Cyanobacteria; Synechococcales; Prochloraceae; OC Prochlorococcus. OX NCBI_TaxID=59922 {ECO:0000313|EMBL:ABM76914.1, ECO:0000313|Proteomes:UP000002274}; RN [1] {ECO:0000313|EMBL:ABM76914.1, ECO:0000313|Proteomes:UP000002274} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MIT 9303 {ECO:0000313|EMBL:ABM76914.1, RC ECO:0000313|Proteomes:UP000002274}; RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231; RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., RA Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., RA Steglich C., Church G.M., Richardson P., Chisholm S.W.; RT "Patterns and implications of gene gain and loss in the evolution of RT Prochlorococcus."; RL PLoS Genet. 3:2515-2528(2007). CC -!- FUNCTION: Important for reducing fluoride concentration in the CC cell, thus reducing its toxicity. {ECO:0000256|HAMAP- CC Rule:MF_00454, ECO:0000256|SAAS:SAAS00096000}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_00454}. CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. CC {ECO:0000256|HAMAP-Rule:MF_00454, ECO:0000256|SAAS:SAAS00573618}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000554; ABM76914.1; -; Genomic_DNA. DR EnsemblBacteria; ABM76914; ABM76914; P9303_01591. DR KEGG; pmf:P9303_01591; -. DR HOGENOM; HOG000052573; -. DR KO; K06199; -. DR OMA; HFEPMVP; -. DR OrthoDB; POG091H017F; -. DR Proteomes; UP000002274; Chromosome. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:UniProtKB-UniRule. DR HAMAP; MF_00454; CrcB; 1. DR InterPro; IPR003691; CrcB. DR PANTHER; PTHR28259; PTHR28259; 1. DR Pfam; PF02537; CRCB; 1. PE 3: Inferred from homology; KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00454}; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702610}; KW Complete proteome {ECO:0000313|Proteomes:UP000002274}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702614}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702612}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702611}; KW Transport {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00096019}. FT TRANSMEM 12 33 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 45 65 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 77 100 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 112 133 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. SQ SEQUENCE 135 AA; 13803 MW; 3E9CE0E61D1D9A5C CRC64; MAGSMSDLAL PAWQASLVAI GAVPGAWLRL RVVNHLEPMV PRKHWGTFAV NMVAAFALGL VLALQAKCAP ASGASPLILL IGVGFFGSLS TFSTFAGEVL NTLREHRWSE ALVLAVGSIL GGLLAVAAGV GLADG //