ID MURE_PROM1 Reviewed; 509 AA. AC A2C0L8; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 20-FEB-2007, sequence version 1. DT 15-JAN-2008, entry version 10. DE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase DE (EC 6.3.2.13) (UDP-N-acetylmuramyl-tripeptide synthetase) (Meso- DE diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase). GN Name=murE; OrderedLocusNames=NATL1_04641; OS Prochlorococcus marinus (strain NATL1A). OC Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae; OC Prochlorococcus. OX NCBI_TaxID=167555; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Chisholm S., Huang K., Martiny A., Kettler G., Coleman M., Keller K., RA Arkin A., Coe A., Rodrigue S., Ferriera S., Johnson J., Kravitz S., RA Beeson K., Sutton G.G., Rogers Y.-H., Friedman R., Frazier M., RA Venter J.C.; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cell wall formation. Diaminopimelic acid adding enzyme CC (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramoyl-L-alanyl-D- CC glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP- CC N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino- CC heptanedioate. CC -!- PATHWAY: Cell wall biosynthesis; peptidoglycan biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable). CC -!- SIMILARITY: Belongs to the murCDEF family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000553; ABM75028.1; -; Genomic_DNA. DR RefSeq; YP_001014293.1; -. DR GeneID; 4780153; -. DR GenomeReviews; CP000553_GR; NATL1_04641. DR KEGG; pme:NATL1_04641; -. DR GO; GO:0008765; F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-...; IEA:EC. DR HAMAP; MF_00208; -; 1. DR InterPro; IPR012237; Mur_ligase. DR InterPro; IPR004101; Mur_ligase_C. DR InterPro; IPR013221; Mur_ligase_cen. DR InterPro; IPR000713; Mur_ligase_N. DR InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase. DR Pfam; PF01225; Mur_ligase; 1. DR Pfam; PF02875; Mur_ligase_C; 1. DR Pfam; PF08245; Mur_ligase_M; 1. DR PIRSF; PIRSF001562; UDP-NAcM_Alig; 1. DR TIGRFAMs; TIGR01085; murE; 1. PE 3: Inferred from homology; KW ATP-binding; Cell cycle; Cell division; Cell shape; KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; KW Ligase; Nucleotide-binding; Peptidoglycan synthesis. FT CHAIN 1 509 UDP-N-acetylmuramoylalanyl-D-glutamate-- FT 2,6-diaminopimelate ligase. FT /FTId=PRO_1000012374. FT NP_BIND 117 123 ATP (Potential). SQ SEQUENCE 509 AA; 56281 MW; D98BD6E69F8DEDFB CRC64; MSRYLHTLLK AIDLQVRSGL ANPEIKNLST DSREIEKGDL FLGLDGEKVD GGTFWAKAIE RGACAAIISK KASLLNPPTN EDPVVILPEP VSLFMGKLAA DFWGKPSSEI CLIGITGTNG KTTTSFLIEF LTTSLGHPSA LFGTLINRWP NYEETSKYTT TFAVPLQAKL RKAVQAGVEY GAMEVSSHAL SQNRVAGCDF NGAIFTNLSR DHLDYHDSME SYFEAKASLF RSHLIDDDGP RSVINIDDKW GSILAKELNK KCWTCSLKEN SQIREKPDLY ISNLQIMQDG YMGKLHTPFG VGNFISPLIG EFNLMNMLQA IGILVQRGLP LNDLLEALNK FPGVPGRMQL INMDGFKVKD GYPLVIVDYA HTPDGLQNAL IASRSLTKKR LICVFGCGGD RDKGKRSKMG EVAAKFADYI VVTSDNPRQE DPIEIIKDIQ KGITIDSEIS VEPERSIAIQ FAIAKAKKND VVLIAGKGHE DYQILKDQTI YFDDREQARK ALSLRTDVI //