ID A2BRA1_PROMS Unreviewed; 328 AA. AC A2BRA1; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 04-DEC-2007, entry version 9. DE Putative Methionyl-tRNA formyltransferase (EC 2.1.2.9). GN Name=fmt; OrderedLocusNames=A9601_10281; OS Prochlorococcus marinus (strain AS9601). OC Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae; OC Prochlorococcus. OX NCBI_TaxID=146891; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Chisholm S., Huang K., Martiny A., Kettler G., Coleman M., Keller K., RA Arkin A., Coe A., Rodrigue S., Ferriera S., Johnson J., Kravitz S., RA Beeson K., Sutton G.G., Rogers Y.-H., Friedman R., Frazier M., RA Venter J.C.; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Modifies the free amino group of the aminoacyl moiety of CC methionyl-tRNA(fMet). The formyl group appears to play a dual role CC in the initiator identity of N-formylmethionyl-tRNA by: (I) CC promoting its recognition by IF2 and (II) impairing its binding to CC EFTu-GTP (By similarity). CC -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + L-methionyl- CC tRNA(fMet) + H(2)O = tetrahydrofolate + N-formylmethionyl- CC tRNA(fMet). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000551; ABM70312.1; -; Genomic_DNA. DR RefSeq; YP_001009419.1; -. DR GeneID; 4717739; -. DR KEGG; pmb:A9601_10281; -. DR GO; GO:0004479; F:methionyl-tRNA formyltransferase activity; IEA:EC. DR InterPro; IPR005794; Fmt. DR InterPro; IPR005793; Formyl_trans_C. DR InterPro; IPR002376; Formyl_transf_N. DR InterPro; IPR015518; Met_tRNA_Form_TA-like. DR Gene3D; G3DSA:3.10.25.10; Formyl_trans_C; 1. DR Gene3D; G3DSA:3.40.50.170; Formyl_transf_N; 1. DR PANTHER; PTHR11138; Met_tRNA_Form_TA-like; 1. DR Pfam; PF02911; Formyl_trans_C; 1. DR Pfam; PF00551; Formyl_trans_N; 1. DR TIGRFAMs; TIGR00460; fmt; 1. PE 3: Inferred from homology; KW Complete proteome; Methyltransferase; Protein biosynthesis; KW Transferase. SQ SEQUENCE 328 AA; 37090 MW; 4AA5388674349BEB CRC64; MRIIFWGTPE YSIASLDIFI KSKHEVIGVV SQPDKKRSRG NKLISSPVKS FAEQESIKIY TPVKIRDNIH FINELKSLSC DLFIVIAYGK ILPKEILEIP KFGCWNAHAS LLPRWRGAAP IQWSLIKGDK FTGVGIMKMN EGLDTGDLLL EEKIKIGNED NLNTLSEKLS ILSAKLFLKA ASLLEENFYK NTKSQLTKQN SLGREITYAR MIEKSDFRVD WGNQAIAISQ KIKGLYPRAN TIFRGKNLKI LKIKVLSSDE IKNEKYLFMS DYSRPGIILA VIEDEGIIIS TKTDPIILLE AKLEGKNISS KKQLIQQLKP SVGEYLSD //