ID   A2AWR3_MOUSE            Unreviewed;       868 AA.
AC   A2AWR3;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   SubName: Full=G protein-coupled receptor 155 {ECO:0000313|Ensembl:ENSMUSP00000107674};
DE   SubName: Full=GPR155 variant 1 {ECO:0000313|EMBL:ADI43225.1};
GN   Name=Gpr155 {ECO:0000313|EMBL:ADI43225.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000107674, ECO:0000313|MGI:MGI:1915776};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000107674, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000107674, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107674,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|EMBL:ADI43225.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:ADI43225.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:ADI43225.1};
RX   PubMed=20537985; DOI=10.1016/j.bbrc.2010.05.162;
RA   Trifonov S., Houtani T., Shimizu J., Hamada S., Kase M., Maruyama M.,
RA   Sugimoto T.;
RT   "GPR155: Gene organization, multiple mRNA splice variants and expression in
RT   mouse central nervous system.";
RL   Biochem. Biophys. Res. Commun. 398:19-25(2010).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000107674}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107674};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [5] {ECO:0000313|EMBL:ADI43225.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:ADI43225.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:ADI43225.1};
RA   Trifonov S., Houtani T., Yamashita Y., Kase M., Maruyama M., Sugimoto T.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; HM161763; ADI43225.1; -; mRNA.
DR   RefSeq; NP_001177226.1; NM_001190297.2.
DR   RefSeq; XP_006500169.1; XM_006500106.1.
DR   SMR; A2AWR3; -.
DR   STRING; 10090.ENSMUSP00000075788; -.
DR   MaxQB; A2AWR3; -.
DR   PRIDE; A2AWR3; -.
DR   ProteomicsDB; 332649; -.
DR   Antibodypedia; 50637; 156 antibodies from 12 providers.
DR   Ensembl; ENSMUST00000076463.12; ENSMUSP00000075788.6; ENSMUSG00000041762.17.
DR   Ensembl; ENSMUST00000112043.8; ENSMUSP00000107674.2; ENSMUSG00000041762.17.
DR   GeneID; 68526; -.
DR   KEGG; mmu:68526; -.
DR   UCSC; uc008kco.3; mouse.
DR   CTD; 151556; -.
DR   MGI; MGI:1915776; Gpr155.
DR   VEuPathDB; HostDB:ENSMUSG00000041762; -.
DR   eggNOG; ENOG502QQ69; Eukaryota.
DR   GeneTree; ENSGT00390000004153; -.
DR   HOGENOM; CLU_018490_0_0_1; -.
DR   OMA; PHGLPEM; -.
DR   OrthoDB; 228997at2759; -.
DR   TreeFam; TF324034; -.
DR   BioGRID-ORCS; 68526; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Gpr155; mouse.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000041762; Expressed in olfactory epithelium and 229 other tissues.
DR   ExpressionAtlas; A2AWR3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050890; P:cognition; ISO:MGI.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd04443; DEP_GPR155; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR037368; GPR155_DEP.
DR   InterPro; IPR004776; Mem_trans.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF03547; Mem_trans; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:A2AWR3,
KW   ECO:0007829|ProteomicsDB:A2AWR3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        40..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        384..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        414..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        519..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        657..678
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        690..711
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          755..833
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          550..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          836..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..855
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   868 AA;  96347 MW;  1D6F8294020358BC CRC64;
     MDSYFSAKNS TLAGDMNATW PASHGFNATG DPPSMSITRL FPALLECFGI VLCGYIAGRA
     NIITSTQAKG LGNFVSRFAL PALLFKNMVV LNFSNVDWAF LYSVLIGKAS VFFIVCVLTL
     LVASPESRFS KAGLFPIFAT QSNDFALGYP IVEALYQSTY PEYLQYIYLV APISLMMLNP
     IGFIFCEIQK SKDTQNASQN KAKIVGLGFL RVLQNPIVFM VFVGIAFNFI LDKKIPVYME
     NFLDGLANSF SGSALFYLGL TMVGKIRRLK KSAFVVLTLL ITAKLLVLPL LCREMVELLD
     KGDSVVNHTS LSNYAFLYGV FPVAPGVAIF ATQFNMEVEI ITSGMVISTF VSAPIMYVSA
     WLLTFPTMDA KPLAYAIQNV SFDISIISLV SLIWSLSILL LSKKYKQLPH MLTANLLIAQ
     TIVCAGMMIW NFVKEKNFVG QILVFVLLYS SLYSTYLWTG LLAVSLFLLK KRESVQLPVG
     IIIISGWGIP ALLVGVLLIT GKHNGDSIDS AFFYGKEQMI TTAVTLFCSI LIAGVSLMCM
     NRTTQAGHYE GFGQSQNHKP VEPGSTAFEE NPAPTNEPEL FPSSIPETSC CSCSLGNGEL
     RCPSIEPVTN SSASGPMPSS FEKTDHCVSR CDSQSCILAQ EEEQYLQSGD PQLTRHVLLC
     LLLIIGLFAN LSSCLWWLFN HETGRLYVEL QFFCAVFNFG QGFISFGIFG LDKHLIILPF
     KRRLEFLWNN KEAAADRESP VSEEIKMTCQ QFVHYHRDLC IRNIVRERRC GAKTSAGTFC
     GCDLVNWLIE VGLASDRGEA VIYGDRLVQG GVIQHITNEY EFRDEYLFYR FLQKSPEQSP
     PARTLRDHQE ESYKEIGHSS PPSVSPKT
//